公开(公告)号：US20210246212A1

公开(公告)日：2021-08-12

申请号：US17096458

申请日：2020-11-12

Applicant: Biogen MA Inc.

Inventor： Joe Salas ,  Karl Hanf ,  Arjan van der Flier ,  Bradley R. Pearse

IPC: C07K16/28 ,  C12N9/64 ,  G01N33/569

Abstract: Antibodies and antibody fragments that specifically bind to glycoprotein IIb/IIIa (GPIIb/IIIa) are disclosed. Chimeric molecules comprising such antibodies or antigen-binding fragments are also disclosed. In addition, methods of using the disclosed antibodies, antibody fragments, and chimeric molecules, e.g., to target agents to platelets and for the treatment or prevention of diseases or disorders are provided.

公开(公告)号：US20170355771A1

公开(公告)日：2017-12-14

申请号：US15521102

申请日：2015-10-23

Applicant: Biogen MA Inc.

Inventor： Joe Salas ,  Karl Hanf ,  Arjan van der Flier ,  Bradley R. Pearse

IPC: C07K16/28 ,  G01N33/569 ,  C12N9/64 ,  A61K39/00

CPC classification number: C07K16/2848 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/33 ,  C07K2319/74 ,  C12N9/6437 ,  C12Y304/21021 ,  G01N33/56966 ,  G01N2333/70557

Abstract: Antibodies and antibody fragments that specifically bind to glycoprotein IIb/IIIa (GPIIb/IIIa) are disclosed. Chimeric molecules comprising such antibodies or antigen-binding fragments are also disclosed. In addition, methods of using the disclosed antibodies, antibody fragments, and chimeric molecules, e.g., to target agents to platelets and for the treatment or prevention of diseases or disorders are provided.