公开(公告)号：US10253295B2

公开(公告)日：2019-04-09

申请号：US14426685

申请日：2013-09-05

申请人： Biomet Manufacturing, LLC

发明人： Alan David Gray

IPC分类号： A61K35/18 ,  C12N5/078 ,  A01N1/02 ,  A61K31/19 ,  A61K31/70

摘要： Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition. The method can be performed at a time proximate to the time of obtaining blood from the donor, or after the blood has been stored for a period of time. The method rejuvenates red blood cells. Incubation may be performed for a period of time sufficient to increase the level of a metabolically-significant compound in the RBCs in the leukoreduced blood to a level essentially equal to levels found in fresh blood, the level being greater than the level of the compound in non-leukoreduced blood mixed with the RBC enhancement composition and incubated for the period of time.