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公开(公告)号：US20210261607A1
公开(公告)日：2021-08-26
申请号：US17155935
申请日：2021-01-22
Applicant: Bioverativ Therapeutics Inc.
Inventor： Lily ZHU , Anxhela KOLE , John KULMAN , Marisol ACOSTA
IPC: C07K1/36 , C07K14/755
Abstract: The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor VIII-specific affinity chromatography, and subjecting the chimeric protein to an AEX chromatography; wherein the chimeric protein comprises a factor VIII protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor VIII activity.
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