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公开(公告)号：US11851482B2
公开(公告)日：2023-12-26
申请号：US17151860
申请日：2021-01-19
申请人： Bioverativ USA Inc.
CPC分类号： C07K16/18 , C07K16/40 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present disclosure provides anti-complement factor Bb antibodies, and compositions comprising the antibodies. The anti-Bb antibodies are useful for treating complement-mediated disorders. The present disclosure provides methods of treating complement-mediated disorders.
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公开(公告)号：US20220204647A1
公开(公告)日：2022-06-30
申请号：US17548135
申请日：2021-12-10
申请人： Bioverativ USA Inc.
摘要： The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
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公开(公告)号：US10934347B2
公开(公告)日：2021-03-02
申请号：US16091447
申请日：2017-04-03
申请人： Bioverativ USA Inc.
IPC分类号： C07K16/18 , A61K39/395 , C07K16/40 , A61K39/00
摘要： The present disclosure provides anti-complement factor Bb antibodies, and compositions comprising the antibodies. The anti-Bb antibodies are useful for treating complement-mediated disorders. The present disclosure provides methods of treating complement-mediated disorders.
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公开(公告)号：US20200079876A1
公开(公告)日：2020-03-12
申请号：US16575265
申请日：2019-09-18
申请人： Bioverativ USA Inc.
IPC分类号： C07K16/40
摘要： The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. In some embodiments, such anti-complement C1s antibodies inhibit proteolytic activity of C1s. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
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公开(公告)号：US20240076363A1
公开(公告)日：2024-03-07
申请号：US18349027
申请日：2023-07-07
申请人： Bioverativ USA Inc.
IPC分类号： C07K16/18
摘要： The present disclosure provides antibodies that specifically bind complement pathway component C1s The present disclosure provides nucleic acids comprising nucleotide sequences encoding the anti-C1s antibodies; and host cells comprising the nucleic acids. The present disclosure provides compositions comprising the anti-C1s antibodies. The present disclosure provides methods of use of the anti-C1s antibodies.
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公开(公告)号：US11246926B2
公开(公告)日：2022-02-15
申请号：US16898908
申请日：2020-06-11
申请人： Bioverativ USA Inc.
发明人： Sandip Panicker , Graham Parry
IPC分类号： C12N15/13 , C12N15/12 , C12N15/10 , A61K39/395 , C07K16/18 , C07K16/28 , A61K39/00 , C07K16/40
摘要： The present disclosure provides humanized anti-C1s antibodies. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the humanized anti-C1s antibodies; and host cells comprising the nucleic acids. The present disclosure provides compositions comprising the humanized anti-C1s antibodies. The present disclosure provides methods of use of the humanized anti-C1s antibodies.
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公开(公告)号：US11192944B2
公开(公告)日：2021-12-07
申请号：US16755461
申请日：2018-10-11
申请人： Bioverativ USA Inc.
发明人： Sandip Panicker , Stephen Moore , Pavel A. Nikitin , Tony Byun , Graham Parry
IPC分类号： C07K16/18
摘要： The present disclosure provides methods of inducing a complement activity on a surface of a cell comprising contacting the cell with an effective amount of an anti-Factor B antibody, wherein the anti-Factor B antibody inhibits dissociation of a C3bBb complex into a Factor Bb and a C3b.
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公开(公告)号：US20200079875A1
公开(公告)日：2020-03-12
申请号：US16561202
申请日：2019-09-05
申请人： Bioverativ USA Inc.
摘要： The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
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公开(公告)号：US20200048332A1
公开(公告)日：2020-02-13
申请号：US16340991
申请日：2017-10-12
申请人： Bioverativ USA Inc.
IPC分类号： C07K16/18
摘要： The present disclosure provides antibodies that specifically bind complement pathway component C1s. The present disclosure provides nucleic acids comprising nucleotide sequences encoding the anti-C1s antibodies; and host cells comprising the nucleic acids. The present disclosure provides compositions comprising the anti-C1s antibodies. The present disclosure provides methods of use of the anti-C1s antibodies.
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公开(公告)号：US10450382B2
公开(公告)日：2019-10-22
申请号：US15385735
申请日：2016-12-20
申请人： Bioverativ USA Inc.
IPC分类号： C07K16/40 , A61K39/395 , C07K16/18 , A01N1/02 , A61K49/00 , A61K49/16 , A61K51/10 , G01N33/68 , A61K39/00
摘要： The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
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