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公开(公告)号：US20050267179A1
公开(公告)日：2005-12-01
申请号：US11132082
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
IPC分类号： A61K31/422 , A61P35/00 , C07D413/02 , C07D413/12
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US07005526B2
公开(公告)日：2006-02-28
申请号：US11132082
申请日：2005-05-18
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Ulrike Reiff , Edgar Voss
IPC分类号： C07D263/32 , C07D249/04 , A61K31/422 , A61K31/4192
CPC分类号： C07D413/12
摘要： Objects of the present invention are the compounds of formula (I) formula (I), their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）式（I）的化合物，化学式id =“CHEM-US-00001”num =“000
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公开(公告)号：US07432291B2
公开(公告)日：2008-10-07
申请号：US11083176
申请日：2005-03-17
IPC分类号： A61K31/41 , C07D249/04
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14
摘要： The present invention provides the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的组合物及其制备方法，以及上述用途， 提及的化合物在控制或预防诸如癌症的疾病中。
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公开(公告)号：US20050209290A1
公开(公告)日：2005-09-22
申请号：US11083176
申请日：2005-03-17
IPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , A61K31/427 , A61K31/422 , C07D413/02 , C07D417/02
CPC分类号： C07D417/12 , C07D413/12 , C07D413/14
摘要： The present invention provides the compounds of formula (I) their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式（I）化合物的药学上可接受的盐或酯，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的组合物及其制备方法，以及上述用途， 提及的化合物在控制或预防诸如癌症的疾病中。
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公开(公告)号：US20050203064A1
公开(公告)日：2005-09-15
申请号：US11073065
申请日：2005-03-04
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
IPC分类号： C07D413/12 , C07D417/12 , A61K31/675 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D263/30 , C07D277/22
CPC分类号： C07D417/12 , C07D413/12
摘要： The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式I化合物的药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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公开(公告)号：US07405231B2
公开(公告)日：2008-07-29
申请号：US11073065
申请日：2005-03-04
申请人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
发明人： Birgit Bossenmaier , Walter-Gunar Friebe , Thomas Friess , Lothar Kling , Matthias Rueth , Edgar Voss
IPC分类号： A61K31/41 , C07D249/04
CPC分类号： C07D417/12 , C07D413/12
摘要： The present invention provides the compounds of formula I their pharmaceutically acceptable salts or esters, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明提供式I化合物的药学上可接受的盐或酯，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。
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公开(公告)号：US07205326B2
公开(公告)日：2007-04-17
申请号：US10833721
申请日：2004-04-28
IPC分类号： A61K31/422 , C07D263/30 , C07D413/02
CPC分类号： C07D413/12 , C07D413/14
摘要： Compounds of formula (I) are useful in the therapy and/or prevention of illnesses with known over-expression of receptor tyrosine kinases of the HER-family like HER-2 and EGFR (HER-1). Accordingly, these compounds are useful for the treatment of diseases such as cancer in humans or animals.
摘要翻译： 式（I）化合物
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8.发明申请Novel arylazole derivatives, their manufacture and use as pharmaceutical agents 失效新型芳基唑衍生物，其制造和用作药剂公开(公告)号：US20050124670A1
公开(公告)日：2005-06-09
申请号：US10965996
申请日：2004-10-15
IPC分类号： A61K31/4155 , A61K31/4192 , A61K31/422 , A61K31/426 , C07D413/14 , C07D417/14 , C07D277/38 , A61K31/427 , C07D413/02 , C07D417/02
CPC分类号： C07D417/14 , C07D413/14
摘要： There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 提供式（I）化合物的药学上可接受的盐，其对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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公开(公告)号：US07247649B2
公开(公告)日：2007-07-24
申请号：US10910765
申请日：2004-08-03
IPC分类号： A61K31/422 , C07D263/30 , C07D413/12
CPC分类号： C07D413/12
摘要： The present invention relates to novel oxazoles of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明涉及式（I）的新颖恶唑，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述用途 控制或预防疾病如癌症的化合物。
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10.发明授权公开(公告)号：US07259262B2
公开(公告)日：2007-08-21
申请号：US10965996
申请日：2004-10-15
IPC分类号： C07D263/32 , C07D277/22 , A01N43/76 , A01N43/78
CPC分类号： C07D417/14 , C07D413/14
摘要： There are presented compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms thereof, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 提供式（I）化合物的药学上可接受的盐，其对映体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在 控制或预防癌症等疾病。
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