公开(公告)号：US20180313826A1

公开(公告)日：2018-11-01

申请号：US15900680

申请日：2018-02-20

Applicant: Board of Regents of the University of Nebraska

Inventor： Geoffrey M. THIELE ,  Daniel R. ANDERSON ,  Michael J. DURYEE

IPC: G01N33/53 ,  A61K49/00 ,  G01N33/564

Abstract: In various embodiments methods are provided for identifying a mammal having an elevated risk for an adverse cardiac event (e.g. an MI) and/or determining the prognosis for the mammal. In certain embodiments the methods comprise determining, or causing to be determined, the presence and/or level of antibodies that bind a malondialdehyde-acetaldheyde adduct (MAA adduct) in a biological sample from the mammal, where an elevated level of anti-MAA adduct antibodies, as compared to the level found in a normal healthy mammal is an indicator that that said mammal has one or more atherosclerotic lesions and/or is at elevated risk for a myocardial infarction.