公开(公告)号：US20030003088A1

公开(公告)日：2003-01-02

申请号：US10135801

申请日：2002-04-30

申请人： Board of Trustees operating Michigan State University

发明人： Ming Sound Tsao ,  James E. Trosko ,  Burra V. Madhukar ,  Lawrence K. Olson ,  Loretta VanCamp

IPC分类号： A61K048/00 ,  C12N005/08 ,  C12N015/86

CPC分类号： C07K14/005 ,  A61K35/12 ,  A61K48/00 ,  C12N5/0676 ,  C12N2501/01 ,  C12N2510/02 ,  C12N2510/04 ,  C12N2710/20022 ,  C12N2710/22022 ,  C12N2740/10043

摘要： A human pancreatic ductal epithelial cell line immortalized with the human papilloma virus E6 and E7 genes which has stem cell-like characteristics and which can be induced to differentiate into ductal-like cells and beta-like cells that produce insulin. The immortal cells or derivative thereof are useful for treating insulin-dependent diabetes and in assays for determining the ability of a chemical to induce pancreatic stem cell differentiation or malignancy.

摘要翻译： 人胰腺导管上皮细胞系与具有干细胞样特征的人乳头状瘤病毒E6和E7基因永生化，并可诱导分化为产生胰岛素的导管样细胞和β样细胞。 永生细胞或其衍生物可用于治疗胰岛素依赖性糖尿病和用于确定化学品诱导胰腺干细胞分化或恶性肿瘤的能力的测定法。