公开(公告)号：US20240342186A1

公开(公告)日：2024-10-17

申请号：US18734077

申请日：2024-06-05

Applicant: Boehringer Ingelheim International GmbH

Inventor： Annekatrin Charlotte HEIMANN ,  Sandra Ruth HANDSCHUH ,  Christoph HOENKE ,  Cédrickx GODBOUT ,  Christian GNAMM ,  Patrick GROSS ,  Marc Alexander GRUNDL ,  Joerg Thomas KLEY ,  Christian Andreas KUTTRUFF ,  Dirk REINART ,  Raphael STUBER ,  Theodor THEIS

IPC: A61K31/5386 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K39/395 ,  A61K45/06 ,  A61P37/06 ,  C07D491/048 ,  C07D519/00

CPC classification number: A61K31/5386 ,  A61K31/4412 ,  A61K31/496 ,  A61K31/519 ,  A61K31/5377 ,  A61K39/3955 ,  A61K45/06 ,  A61P37/06 ,  C07D491/048 ,  C07D519/00

Abstract: The invention relates to new proline derivatives of formula (I) as cGAS inhibitors,






wherein
wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and G are defined as in claim 1,
and prodrugs or pharmaceutically acceptable salts of these compounds
for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), non-alcoholic steatotic hepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).

公开(公告)号：US20240189315A1

公开(公告)日：2024-06-13

申请号：US18501509

申请日：2023-11-03

Applicant: Boehringer Ingelheim International GmbH

Inventor： Annekatrin Charlotte HEIMANN ,  Christian GNAMM ,  Cédrickx GODBOUT ,  Sandra Ruth HANDSCHUH ,  Christoph HOENKE ,  Joerg Thomas KLEY ,  Christian Andreas KUTTRUFF ,  Jun LI ,  Dirk REINERT ,  Raphael STUBER ,  Theodor THEIS

IPC: A61K31/529 ,  A61K31/4418 ,  A61K31/496 ,  A61K39/395 ,  A61K45/06 ,  C07D498/22

CPC classification number: A61K31/529 ,  A61K31/4418 ,  A61K31/496 ,  A61K39/3955 ,  A61K45/06 ,  C07D498/22

Abstract: The invention relates to compounds of formula I




wherein R1, R2, R3, R4, A, D, E, G, J, K and L are defined as in claim 1, and prodrugs, deuterated analogues and pharmaceutical acceptable salts thereof, for the treatment of diseases such as systemic lupus erythematosus, systemic sclerosis (SSc), interferonopathies, non-alcoholic steatohepatitis (NASH), interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF).