公开(公告)号：US20030232817A1

公开(公告)日：2003-12-18

申请号：US10372333

申请日：2003-02-24

申请人： Boehringer Ingelheim Pharmaceuticals, Inc.

发明人： Roman Wolfgang Fleck

IPC分类号： C07D487/02 ,  A61K031/541 ,  A61K031/5377 ,  A61K031/53 ,  A61K031/52 ,  A61K031/517 ,  A61K031/502 ,  A61K031/501 ,  A61K031/497 ,  A61K031/4188 ,  A61K031/4745 ,  A61K031/4439

CPC分类号： C07D487/04 ,  A61K31/4188 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/501 ,  A61K31/502 ,  A61K31/517 ,  A61K31/52 ,  A61K31/53 ,  A61K31/5377 ,  A61K31/541

摘要： Compounds of the formula I 1 which are useful for treating or preventing inflammatory and immune cell-mediated diseases.

摘要翻译： 可用于治疗或预防炎症和免疫细胞介导的疾病的式I化合物。

公开(公告)号：US20040180922A1

公开(公告)日：2004-09-16

申请号：US10730172

申请日：2003-12-06

申请人： Boehringer Ingelheim Pharmaceuticals, Inc.

发明人： Charles L. Cywin ,  Can Mao ,  Jonathan Emeigh ,  Roman Wolfgang Fleck ,  Ming-Hong Hao ,  Eugene Hickey ,  Weimin Liu ,  Daniel Richard Marshall ,  Tina Morwick ,  Peter Nemoto ,  Ronald John Sorcek ,  Sanxing Sun ,  Jiang-Ping Wu ,  Erick Young ,  Darren DiSalvo ,  John Ginn ,  Pier Cirillo

IPC分类号： A61K031/4743

CPC分类号： A61K31/38 ,  A61K31/435 ,  C07D495/04

摘要： Disclosed are compounds of formula (I): 1 wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the InullB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

公开(公告)号：US20040053957A1

公开(公告)日：2004-03-18

申请号：US10453175

申请日：2003-06-03

申请人： Boehringer Ingelheim Pharmaceuticals, Inc.

发明人： Charles L. Cywin ,  Zhidong Chen ,  Roman Wolfgang Fleck ,  Ming-Hong Hao ,  Eugene Hickey ,  Weimin Liu ,  Daniel Richard Marshall ,  Peter Nemoto ,  Ronald John Sorcek ,  Sanxing Sun ,  Jiang-Ping Wu ,  Tina Morwick ,  Jonathan Emeigh

IPC分类号： C07D498/02 ,  A61K031/4743

CPC分类号： C07D495/04 ,  A61K31/38 ,  A61K31/435 ,  C08G63/6956 ,  C08G63/916

摘要： Disclosed are compounds of formula (I): 1 wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the InullB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

摘要翻译： 公开了式（I）的化合物：其中R 1和R 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。