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公开(公告)号：US06538112B2
公开(公告)日：2003-03-25
申请号：US09823444
申请日：2001-03-30
IPC分类号： C07K1600
CPC分类号： C07K16/2848 , A61K38/00 , C07K2317/24 , G01N33/68 , G01N33/6893 , G01N2333/70557
摘要： The present invention is a method for diagnosing a patient at risk to thrombocytopenia induced by administration of a GP IIb/IIIa receptor antagonist, which comprises combining i) a plasma sample of the patient; ii) detectable monoclonal antibody which recognizes induced binding sites formed on the GP IIb/IIIa receptor following association of a fibrinogen receptor antagonist with the GP IIb/IIIa receptor; and iii) GP IIb/IIIa receptor:GP IIb/III receptor antagonist complex, and determining association of the detectable monoclonal antibody with the complex in the presence of the plasma.
摘要翻译： 本发明是一种用于诊断通过给予GP IIb / IIIa受体拮抗剂诱导的血小板减少症的患者的方法，所述方法包括组合患者的血浆样品; ii）识别诱导结合位点上形成的诱导结合位点的可检测单克隆抗体 GP IIb / IIIa受体与纤维蛋白原受体拮抗剂与GP IIb / IIIa受体结合后， 和ii）GP IIb / IIIa受体：GP IIb / III受体拮抗剂复合物，以及在血浆存在下确定可检测单克隆抗体与复合物的缔合。
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公开(公告)号：US06210904B1
公开(公告)日：2001-04-03
申请号：US09170858
申请日：1998-10-13
IPC分类号： G01N3353
CPC分类号： C07K16/2848 , A61K38/00 , C07K2317/24 , G01N33/68 , G01N33/6893 , G01N2333/70557
摘要： The present invention is a method for diagnosing a patient at risk to thrombocytopenia induced by administration of a GP IIb/IIIa receptor antagonist, which comprises combining i) a plasma sample of the patient; ii) detectable monoclonal antibody which recognizes induced binding sites formed on the GP IIb/IIIa receptor following association of a fibrinogen receptor antagonist with the GP IIb/IIIa receptor; and iii) GP IIb/IIIa receptor:GP IIb/III receptor antagonist complex, and determining association of the detectable monoclonal antibody with the complex in the presence of the plasma.
摘要翻译： 本发明是一种用于诊断通过给予GP IIb / IIIa受体拮抗剂诱导的血小板减少症的患者的方法，所述方法包括组合患者的血浆样品; ii）识别诱导结合位点上形成的诱导结合位点的可检测单克隆抗体 GP IIb / IIIa受体与纤维蛋白原受体拮抗剂与GP IIb / IIIa受体结合后， 和ii）GP IIb / IIIa受体：GP IIb / III受体拮抗剂复合物，以及在血浆存在下确定可检测单克隆抗体与复合物的缔合。
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