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公开(公告)号：US20220226655A1
公开(公告)日：2022-07-21
申请号：US17712988
申请日：2022-04-04
发明人： Dennis Allen Vansickle , Dongchul Lee , Sridhar Kothandaraman , Que T. Doan , Changfang Zhu , Jordi Parramon , Justin Holley , Bradley L. Hershey , Christopher E. Gillespie , Rafael Carbunaru , Nazim Wahab
摘要： An external control device and method for programming an implantable neuromodulator coupled to an electrode array implanted adjacent tissue of a patient having a medical condition. Electrical modulation energy is conveyed to tissue of the patient in accordance with a series of modulation parameter sets. The patient perceives paresthesia in response to the conveyance of the electrical modulation energy to the tissue in accordance with at least one of the modulation parameter sets. One of the modulation parameter set(s) is identified based on the perceived paresthesia. Another modulation parameter set is derived from the identified modulation parameter set. Electrical modulation energy is conveyed to the tissue of the patient in accordance with the other modulation parameter set without causing the patient to perceive paresthesia.
An external control device, neuromodulation system, and method of providing therapy to a patient. Electrical modulation energy is delivered to a target tissue site of the patient at a programmed amplitude value, thereby providing therapy to the patient without the perception of paresthesia. Electrical modulation energy is delivered to the patient at a series of incrementally increasing amplitude values relative to the programmed amplitude value until the patient perceives paresthesia. A decreased amplitude value is automatically computed as a function of one of the series of incrementally increased amplitude values at which the delivered electrical modulation caused the patient to perceive the paresthesia. Electrical modulation energy is delivered to the target tissue site of the patient at the computed amplitude value, thereby providing therapy to the patient without the perception of paresthesia.-
公开(公告)号：US20220088392A1
公开(公告)日：2022-03-24
申请号：US17457366
申请日：2021-12-02
发明人： Emanuel Feldman , Jordi Parramon , Paul J. Griffith , Jess Shi , Robert Tong , Goran Marnfeldt
摘要： A new architecture is disclosed for an IPG having a master and slave electrode driver integrated circuits (ICs). The electrode outputs on the ICs are wired together. Each IC can be programmed to provide pulses with different frequencies. Active timing channels in master and slave ICs are programmed to provide the desired pulses, while shadow timing channels in the master and slave are programmed with the timing data from the active timing channels in the other IC so that each chip knows when the other is providing a pulse, so that each chip can disable its recovery circuitry so as not to defeat those pulses. In the event of pulse overlap at a given electrode, the currents provided by each chip will add at the affected electrode. Compliance voltage generation is dictated by an algorithm to find an optimal compliance voltage even during periods when pulses are overlapping.
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公开(公告)号：US10940317B2
公开(公告)日：2021-03-09
申请号：US16359583
申请日：2019-03-20
摘要： A therapeutic neuromodulation system configured for providing therapy to a patient. The therapeutic neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes implanted within tissue, analog output circuitry configured for delivering therapeutic electrical energy between the plurality of electrical terminals in accordance with a set of modulation parameters that includes a defined current value, a voltage regulator configured for supplying an adjustable compliance voltage to the analog output circuitry, and control/processing circuitry configured for automatically performing a compliance voltage calibration process at a compliance voltage adjustment interval by periodically computing an adjusted compliance voltage value as a function of a compliance voltage margin. The control/processing circuitry may also be configured for automatically adjusting at least one of the compliance voltage adjustment interval and the compliance voltage margin during the compliance voltage calibration process.
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公开(公告)号：US20200346007A1
公开(公告)日：2020-11-05
申请号：US16930817
申请日：2020-07-16
摘要： Recovery circuitry for passively recovering charge from capacitances at electrodes in an Implantable Pulse Generator (IPG) is disclosed. The passive recovery circuitry includes passive recovery switches intervening between each electrode node and a common reference voltage, and each switch is in series with a variable resistance that may be selected based on differing use models of the IPG. The passive recovery switches may also be controlled in different modes. For example, in a first mode, the only recovery switches closed after a stimulation pulse are those associated with electrodes used to provide stimulation. In a second mode, all recovery switches are closed after a stimulation pulse, regardless of the electrodes used to provide stimulation. In a third mode, all recovery switches are closed continuously, which can provide protection when the IPG is in certain environments (e.g., MRI), and which can also be used during stimulation therapy itself.
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公开(公告)号：US10806930B2
公开(公告)日：2020-10-20
申请号：US15879095
申请日：2018-01-24
摘要： An algorithm programmed into the control circuitry of a rechargeable-battery Implantable Medical Device (IMD) is disclosed that can quantitatively forecast and determine the timing of an early replacement indicator (tEOLi) and an IMD End of Life (tEOL). These forecasts and determinations of tEOLi and tEOL occur in accordance with one or more parameters having an effect on rechargeable battery capacity, such as number of charging cycles, charging current, discharge depth, load current, and battery calendar age. The algorithm consults such parameters as stored over the history of the operation of the IMD in a parameter log, and in conjunction with a battery capacity database reflective of the effect of these parameters on battery capacity, determines and forecasts tEOLi and tEOL. Such forecasted or determined values may also be used by a shutdown algorithm to suspend therapeutic operation of the IMD.
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公开(公告)号：US10420950B2
公开(公告)日：2019-09-24
申请号：US15334043
申请日：2016-10-25
摘要： An implantable pulse generator (IPG) allowing for trial stimulation in a fully implanted solution is disclosed. At the time the leads are implanted, a micro IPG having lead connection block(s) is also implanted and connected to the leads. To keep the micro IPG suitably small, it preferably does not include a battery, and is instead powered continuously via magnetic induction using a magnetic field produced by an external charger, such as a charging patch. A coil in the micro IPG picks up and rectifies this magnetic field to provide power to stimulating electronics in the IPG. Because of its small size (e.g., ≤10 cm3), implantation of the micro IPG can occur at the same time the leads are implanted in the patient without inconvenience. Should stimulation therapy with the micro IPG prove effective, a larger, permanent IPG can later be implanted and connected to the implanted leads.
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公开(公告)号：US10391313B2
公开(公告)日：2019-08-27
申请号：US15367491
申请日：2016-12-02
发明人： Michael A. Moffitt , G. Karl Steinke , Sridhar Kothandaraman , Bradley Lawrence Hershey , Changfang Zhu , Jordi Parramon , Goran N. Marnfeldt , John Rivera , Stephen Carcieri
摘要： Methods, devices and systems for developing new therapy options for patient suffering from neurological disorders. An example may include the use of a therapy patterning system that allows significant freedom to program therapy patterns using arbitrary shapes and functions. For such patterning to be implemented, a physician may identify a condition needing new and/or alternative therapy options, link the identified condition one or more therapy parameters, program, test and assess the therapy. The process may include multiple iterations to address an initial condition and then to mitigate side effects of the initial therapy. Some embodiments comprises devices configured to deliver combinations of therapy patterns to accomplish at least first and second therapeutic purposes.
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公开(公告)号：US10307595B2
公开(公告)日：2019-06-04
申请号：US15421926
申请日：2017-02-01
摘要： A therapeutic neuromodulation system configured for providing therapy to a patient. The therapeutic neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to a plurality of electrodes implanted within tissue, analog output circuitry configured for delivering therapeutic electrical energy between the plurality of electrical terminals in accordance with a set of modulation parameters that includes a defined current value, a voltage regulator configured for supplying an adjustable compliance voltage to the analog output circuitry, and control/processing circuitry configured for automatically performing a compliance voltage calibration process at a compliance voltage adjustment interval by periodically computing an adjusted compliance voltage value as a function of a compliance voltage margin. The control/processing circuitry may also be configured for automatically adjusting at least one of the compliance voltage adjustment interval and the compliance voltage margin during the compliance voltage calibration process.
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公开(公告)号：US10252049B2
公开(公告)日：2019-04-09
申请号：US15195162
申请日：2016-06-28
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. A train of electrical stimulation pulses is conveyed within a stimulation timing channel between a group of the electrodes to stimulate neural tissue, thereby providing continuous therapy to the patient. Electrical parameter is sensed within a sensing timing channel using at least one of the electrodes, wherein the first stimulation timing channel and sensing timing channel are coordinated, such that the electrical parameter is sensed during the conveyance of the pulse train within time slots that do not temporally overlap any active phase of the stimulation pulses.
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10.发明申请公开(公告)号：US20180345007A1
公开(公告)日：2018-12-06
申请号：US16102302
申请日：2018-08-13
发明人： Jordi Parramon , Rafael Carbunaru
CPC分类号： A61N1/05 , A61N1/36125 , A61N1/36185 , A61N1/3686 , A61N1/37205
摘要： Architectures for implantable stimulators having N electrodes are disclosed. The architectures contains X current sources, or DACs. In a single anode/multiple cathode design, one of the electrodes is designated as the anode, and up to X of the electrodes can be designated as cathodes and independently controlled by one of the X DACs, allowing complex patient therapy and current steering between electrodes. The design uses at least X decoupling capacitors: X capacitors in the X cathode paths, or one in the anode path and X−1 in the X cathode paths. In a multiple anode/multiple cathode design having X DACs, a total of X−1 decoupling capacitors are needed. Because the number of DACs X can typically be much less than the total number of electrodes (N), these architectures minimize the number of decoupling capacitors which saves space, and ensures no DC current injection even during current steering.
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