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1.发明授权Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications 失效回肠胆汁酸运输抑制剂和心血管适应症胆汁酸螯合剂的组合公开(公告)号：US06562860B1
公开(公告)日：2003-05-13
申请号：US09466592
申请日：1999-12-17
IPC分类号： A61K3138
CPC分类号： A61K31/585 , A61K31/55 , A61K31/575 , A61K31/785 , A61K45/06 , Y10S514/824 , A61K2300/00
摘要： The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include an ileal bile acid transport inhibitor combined with a bile acid sequestrant.
摘要翻译： 本发明提供用于预防或治疗包括高胆固醇血症，动脉粥样硬化或高脂血症的心血管疾病的心血管治疗化合物的组合。 公开的组合包括与胆汁酸螯合剂组合的回肠胆汁酸转运抑制剂。
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2.发明授权Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications 失效回肠胆汁酸转运抑制剂和纤维酸衍生物用于心血管适应症的组合公开(公告)号：US06638969B1
公开(公告)日：2003-10-28
申请号：US09465642
申请日：1999-12-17
IPC分类号： A61K3138
CPC分类号： A61K45/06 , A61K31/192 , A61K31/216 , A61K31/554 , Y10S514/824 , A61K2300/00
摘要： The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include an ileal bile acid transport inhibitor combined with a fibric acid derivative.
摘要翻译： 本发明提供用于预防或治疗包括高胆固醇血症，动脉粥样硬化或高脂血症的心血管疾病的心血管治疗化合物的组合。 公开的组合包括与纤维酸衍生物组合的回肠胆汁酸转运抑制剂。
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3.发明授权Combinations of ileal bile acid transport inhibitors and cholesteryl ester transfer protein inhibitors for cardiovascular indications 失效回肠胆汁酸转运抑制剂与心血管适应症胆固醇酯转运蛋白抑制剂的组合公开(公告)号：US06458851B1
公开(公告)日：2002-10-01
申请号：US09466415
申请日：1999-12-17
申请人： Bradley T. Keller , James A. Sikorski , Kevin C. Glenn , Daniel T. Connolly , Mark E. Smith , Joseph R. Schuh
发明人： Bradley T. Keller , James A. Sikorski , Kevin C. Glenn , Daniel T. Connolly , Mark E. Smith , Joseph R. Schuh
IPC分类号： A61K314995
CPC分类号： A61K31/585 , A61K31/55 , A61K31/575 , A61K31/785 , A61K45/06 , Y10S514/824 , A61K2300/00
摘要： The present invention provides combinations of cardiovascular therapeutic compounds for the prophylaxis or treatment of cardiovascular disease including hypercholesterolemia, atherosclerosis, or hyperlipidemia. Combinations disclosed include an ileal bile acid transport inhibitor combined with a cholesteryl ester transfer protein (CETP) inhibitor.
摘要翻译： 本发明提供用于预防或治疗包括高胆固醇血症，动脉粥样硬化或高脂血症的心血管疾病的心血管治疗化合物的组合。 公开的组合包括与胆固醇酯转移蛋白（CETP）抑制剂组合的回肠胆汁酸转运抑制剂。
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4.发明授权Method to treat cardiofibrosis with a combination therapy of an angiotensin II antagonist and epoxymexrenone 失效用联合治疗血管紧张素II拮抗剂和环氧基异丙肾上腺素治疗心纤维化的方法公开(公告)号：US06984633B2
公开(公告)日：2006-01-10
申请号：US10371699
申请日：2003-02-21
IPC分类号： A61K31/56 , A61K31/58 , A61K31/585 , A61K31/41 , A61K31/535
CPC分类号： A61K31/58 , A61K45/06 , A61K2300/00
摘要： A therapeutic method is described for treating cardiofibrosis or cardiac hypertrophy using a combination therapy comprising a therapeutically-effective amount of an angiotensin II receptor antagonist and a therapeutically-effective amount of expoxymexrenone.
摘要翻译： 描述了使用包含治疗有效量的血管紧张素II受体拮抗剂和治疗有效量的外消旋异丙肾上腺素的联合疗法治疗心纤维化或心脏肥大的治疗方法。
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5.发明授权Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy 失效环氧甾体醛固酮拮抗剂和血管紧张素II拮抗剂联合治疗公开(公告)号：US06653306B1
公开(公告)日：2003-11-25
申请号：US08781786
申请日：1997-01-09
IPC分类号： A61K31535
CPC分类号： A61K45/06 , A61K31/585 , A61K31/41 , A61K2300/00
摘要： A combination comprising therapeutically-effective amount of an epoxy-steroidal aldosterone receptor antagonist and a therapeutically-effective amount of an angiotensin II receptor antagonist is described for treatment of circulatory disorders.
摘要翻译： 描述了包含治疗有效量的环氧甾体醛固酮受体拮抗剂和治疗有效量的血管紧张素II受体拮抗剂的组合，用于治疗循环系统疾病。
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