公开(公告)号：US20070009533A1

公开(公告)日：2007-01-11

申请号：US11417984

申请日：2006-05-03

申请人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K39/395 ,  A61K38/13 ,  A61K31/553 ,  A61K31/551 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/704 ,  A61K31/277 ,  A61K31/138

CPC分类号： A61K38/13 ,  A61K31/138 ,  A61K31/277 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/551 ,  A61K31/553 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a method of determining P-glycoprotein expression and/or function for a patient with solid tumors, leukemias, and other malignancies. The invention also relates to using a P-glycoprotein expression and/or function diagnostic in conjunction with methods for treating solid tumors, leukemias, and other malignancies with a chemotherapeutic agent in combination with zosuquidar. The methods are particularly effective in treating acute myelogenous leukemia, metastatic breast cancer, and other cancers expressing P-glycoprotein, wherein the P-glycoprotein expression and/or function is used to select a treatment option for the patient.

公开(公告)号：US20070009531A1

公开(公告)日：2007-01-11

申请号：US11416833

申请日：2006-05-03

申请人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K39/395 ,  A61K31/4709

CPC分类号： A61K31/4709 ,  A61K39/39558 ,  A61K2300/00

摘要： The present invention relates to a method of treating patients with solid tumors, leukemias, and other malignancies using a combination of zosuquidar and a calicheamicin-antibody conjugate, such as Mylotarg. The invention is also directed to pharmaceutical formulations comprising zosuquidar and calicheamicin-antibody conjugates. The formulations are particularly effective in treating relapsed Acute Myelogenous Leukemia (AML) and metastatic breast cancer.

摘要翻译： 本发明涉及使用佐剂和卡里霉素 - 抗体缀合物如Mylotarg的组合来治疗患有实体瘤，白血病和其它恶性肿瘤的患者的方法。 本发明还涉及包含佐剂和加利车霉素 - 抗体缀合物的药物制剂。 该制剂在治疗复发性急性骨髓性白血病（AML）和转移性乳腺癌中特别有效。

公开(公告)号：US20070010465A1

公开(公告)日：2007-01-11

申请号：US11416571

申请日：2006-05-03

申请人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K31/704 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/337

CPC分类号： A61K31/4709 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/704 ,  A61K31/7072 ,  A61K2300/00

摘要： The present invention relates to a method of treating patients with solid tumors, leukemias, and other malignancies using a combination of zosuquidar, daunorubicin, and cytarabine. The invention is also directed to pharmaceutical formulations comprising zosuquidar, daunorubicin, and cytarabine. The formulations are particularly effective in treating relapsed Acute Myelogenous Leukemia (AML).

公开(公告)号：US20070009532A1

公开(公告)日：2007-01-11

申请号：US11416992

申请日：2006-05-03

申请人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K39/395 ,  A61K31/4709

CPC分类号： A61K31/4709 ,  A61K39/39558 ,  A61K2300/00

摘要： The present invention relates to a method of treating patients with solid tumors, leukemias, and other malignancies using a combination of zosuquidar and a calicheamicin-antibody conjugate, such as Mylotarg. The invention is also directed to pharmaceutical formulations comprising zosuquidar and calicheamicin-antibody conjugates. The formulations are particularly effective in treating relapsed Acute Myelogenous Leukemia (AML) and metastatic breast cancer.

公开(公告)号：US20070010486A1

公开(公告)日：2007-01-11

申请号：US11418324

申请日：2006-05-03

申请人： Jeff Schwegman ,  Mark Edgar ,  Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Jeff Schwegman ,  Mark Edgar ,  Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K31/724

CPC分类号： A61K47/40 ,  A61K9/0019 ,  A61K31/724 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a method of treating patients with leukemias, solid tumors, and other malignancies using chemotherapeutic agents in combination with zosuquidar that has been solubilized by a modified cyclodextrin, such as sulfobutylcyclodextrin or hydroxypropyl cyclodextrin. The invention is also directed to pharmaceutical formulations comprising zosuquidar in combination with a modified cyclodextrin.

公开(公告)号：US20070010485A1

公开(公告)日：2007-01-11

申请号：US11417958

申请日：2006-05-03

申请人： Jeff Schwegman ,  Mark Edgar ,  Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Jeff Schwegman ,  Mark Edgar ,  Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K31/724

CPC分类号： A61K31/496 ,  A61K31/724 ,  A61K2300/00

摘要： The present invention relates to a method of treating patients with leukemias, solid tumors, and other malignancies using chemotherapeutic agents in combination with zosuquidar that has been solubilized by a modified cyclodextrin, such as sulfobutylcyclodextrin or hydroxypropyl cyclodextrin. The invention is also directed to pharmaceutical formulations comprising zosuquidar in combination with a modified cyclodextrin.

摘要翻译： 本发明涉及使用已被改性环糊精如磺丁基环糊精或羟丙基环糊精溶解的化学治疗剂与佐剂相结合来治疗白血病，实体瘤和其他恶性肿瘤的患者的方法。 本发明还涉及包含与改性环糊精组合的佐剂的药物制剂。

公开(公告)号：US20070009535A1

公开(公告)日：2007-01-11

申请号：US11418399

申请日：2006-05-03

申请人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K39/395 ,  G01N33/574 ,  A61K31/704 ,  A61K31/525 ,  A61K31/4745 ,  A61K31/4709

CPC分类号： G01N33/57426 ,  G01N2800/44

摘要： The present invention relates to a method of determining P-glycoprotein expression and/or function for a patient with solid tumors, leukemias, and other malignancies. The invention also relates to using a P-glycoprotein expression and/or function diagnostic in conjunction with methods for treating solid tumors, leukemias, and other malignancies with a chemotherapeutic agent in combination with zosuquidar. The methods are particularly effective in treating acute myelogenous leukemia, metastatic breast cancer, and other cancers expressing P-glycoprotein, wherein the P-glycoprotein expression and/or function is used to select a treatment option for the patient.

摘要翻译： 本发明涉及确定具有实体瘤，白血病和其他恶性肿瘤的患者的P-糖蛋白表达和/或功能的方法。 本发明还涉及使用P-糖蛋白表达和/或功能诊断与结合用于治疗实体瘤，白血病和其它恶性肿瘤的化疗剂与佐剂相结合的方法。 所述方法在治疗急性骨髓性白血病，转移性乳腺癌和表达P-糖蛋白的其它癌症中特别有效，其中P-糖蛋白表达和/或功能用于选择患者的治疗选择。

公开(公告)号：US20070010487A1

公开(公告)日：2007-01-11

申请号：US11418400

申请日：2006-05-03

申请人： Jeff Schwegman ,  Mark Edgar ,  Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Jeff Schwegman ,  Mark Edgar ,  Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K31/724

CPC分类号： A61K45/06 ,  A61K31/496 ,  A61K31/724 ,  A61K2300/00

摘要： The present invention relates to a method of treating patients with leukemias, solid tumors, and other malignancies using chemotherapeutic agents in combination with zosuquidar that has been solubilized by a modified cyclodextrin, such as sulfobutylcyclodextrin or hydroxypropyl cyclodextrin. The invention is also directed to pharmaceutical formulations comprising zosuquidar in combination with a modified cyclodextrin.

公开(公告)号：US20070010478A1

公开(公告)日：2007-01-11

申请号：US11416829

申请日：2006-05-03

申请人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K31/7072 ,  A61K31/4709 ,  A61K31/704

CPC分类号： A61K31/4709 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/704 ,  A61K31/7072 ,  A61K2300/00

摘要： The present invention relates to a method of treating patients with solid tumors, leukemias, and other malignancies using a combination of zosuquidar, daunorubicin, and cytarabine. The invention is also directed to pharmaceutical formulations comprising zosuquidar, daunorubicin, and cytarabine. The formulations are particularly effective in treating relapsed Acute Myelogenous Leukemia (AML).

公开(公告)号：US20070010466A1

公开(公告)日：2007-01-11

申请号：US11416832

申请日：2006-05-03

申请人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

发明人： Branimir Sikic ,  Daniel Hoth ,  David Socks ,  Scott Glenn ,  John Marcelletti ,  Michael Walsh ,  Pratik Multani

IPC分类号： A61K31/7072 ,  A61K31/704 ,  A61K31/4709

CPC分类号： A61K31/4709 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/704 ,  A61K31/7072 ,  A61K2300/00

摘要： The present invention relates to a method of treating patients with solid tumors, leukemias, and other malignancies using a combination of zosuquidar, daunorubicin, and cytarabine. The invention is also directed to pharmaceutical formulations comprising zosuquidar, daunorubicin, and cytarabine. The formulations are particularly effective in treating relapsed Acute Myelogenous Leukemia (AML).

摘要翻译： 本发明涉及使用佐剂，柔红霉素和阿糖胞苷的组合来治疗患有实体瘤，白血病和其他恶性肿瘤的患者的方法。 本发明还涉及包含佐剂，柔红霉素和阿糖胞苷的药物制剂。 该制剂在治疗复发性急性骨髓性白血病（AML）中特别有效。