公开(公告)号：US20190309266A1

公开(公告)日：2019-10-10

申请号：US16378209

申请日：2019-04-08

申请人： Braskem S.A.

发明人： Verônica Leite QUEIROZ ,  Lucas Pedersen PARIZZI ,  Iuri Estrada GOUVEA ,  Debora Noma OKAMOTO ,  Rafael Victório Carvalho GUIDO ,  Alessandro Silva NASCIMENTO ,  Igor POLIKARPOV

IPC分类号： C12N9/04 ,  C12N15/52

摘要： The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.

公开(公告)号：US20230279365A1

公开(公告)日：2023-09-07

申请号：US18084888

申请日：2022-12-20

申请人： Braskem S.A.

发明人： Verônica Leite QUEIROZ ,  Lucas Pedersen PARIZZI ,  Iuri Estrada GOUVEA ,  Debora Noma OKAMOTO ,  Rafael Victório Carvalho GUIDO ,  Alessandro Silva NASCIMENTO ,  Igor POLIKARPOV

IPC分类号： C12N9/04 ,  C12N15/52

CPC分类号： C12N9/0006 ,  C12N15/52 ,  C12Y101/01001

摘要： The present disclosure relates to biological processes and systems for the production of isopropanol and/or acetone utilizing modified alcohol dehydrogenases that exhibit increased activity with NADH as a cofactor. The disclosure further relates to polynucleotides and polypeptides of the modified alcohol dehydrogenases, and host cells containing the polynucleotides and expressing the polypeptides.