公开(公告)号：US20070059709A1

公开(公告)日：2007-03-15

申请号：US10624725

申请日：2003-07-21

申请人： Bret Benton ,  Ving Lee ,  Francois Malouin ,  Patrick Martin ,  Molly Schmid ,  Dongxu Sun

发明人： Bret Benton ,  Ving Lee ,  Francois Malouin ,  Patrick Martin ,  Molly Schmid ,  Dongxu Sun

IPC分类号： C12Q1/68 ,  G01N33/554 ,  A61K31/4196 ,  A61K31/4439

CPC分类号： C07K14/31 ,  A61K31/4196 ,  A61K31/4439 ,  G01N33/56938

摘要： This disclosure describes isolated or purified deoxyribonucleotide (DNA) sequences, useful for the development of antibacterial agents, which contain the coding sequences of bacterial pathogenesis genes or essential genes, which are expressed in vivo. It further describes isolated or purified DNA sequences which are portions of such bacterial genes, which are useful as probes to identify the presence of the corresponding gene or the presence of a bacteria containing that gene. Also described are hypersensitive mutant cells containing a mutant gene corresponding to any of the identified sequences and methods of screening for antibacterial agents using such hypersensitive cells. In addition it describes methods of treating bacterial infections by administering an antibacterial agent active against one of the identified targets, as well as pharmaceutical compositions effective in such treatments.

摘要翻译： 本公开描述了分离或纯化的脱氧核糖核苷酸（DNA）序列，其用于开发抗菌剂，其含有在体内表达的细菌发病基因或必需基因的编码序列。 它进一步描述了分离或纯化的DNA序列，其是这些细菌基因的部分，其可用作鉴定相应基因的存在的探针或含有该基因的细菌的存在。 还描述了含有与任何鉴定的序列相对应的突变基因的超敏感突变体细胞和使用这种超敏感细胞筛选抗菌剂的方法。 此外，它描述了通过施用对一种鉴定的靶标具有活性的抗菌剂以及在这种治疗中有效的药物组合物来治疗细菌感染的方法。

公开(公告)号：US20060142265A1

公开(公告)日：2006-06-29

申请号：US11231298

申请日：2005-09-19

申请人： Judd Berman ,  Molly Schmid ,  John Mendlein ,  Nachum Kaplan

发明人： Judd Berman ,  Molly Schmid ,  John Mendlein ,  Nachum Kaplan

IPC分类号： A61K31/554 ,  A61K31/517 ,  A61K31/55 ,  A61K31/4745 ,  A61K31/496

CPC分类号： A61K45/06 ,  A61K31/381 ,  A61K31/4422 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/517 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/5513 ,  A61K31/554 ,  A61K2300/00

摘要： In part, the present invention is directed to compositions comprising a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions comprising a compound of formulas I-III and at least one other antibacterial agent.

摘要翻译： 部分地，本发明涉及包含FabI抑制剂和至少一种其它生物活性剂的组合物。 另一方面，本发明涉及包含式I-III化合物和至少一种其它抗菌剂的抗菌组合物。