公开(公告)号：US06981972B1

公开(公告)日：2006-01-03

申请号：US09483969

申请日：2000-01-18

申请人： Brian E. Farley ,  Michael D. Laufer ,  Dawn A. Henderson ,  Douglas M. Petty ,  Mark P. Parker

发明人： Brian E. Farley ,  Michael D. Laufer ,  Dawn A. Henderson ,  Douglas M. Petty ,  Mark P. Parker

IPC分类号： A61B17/38

CPC分类号： A61B18/1492 ,  A61B17/00008 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00702 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

摘要： A catheter introduces electrodes in a vein for a minimally invasive treatment of venous insufficiency by the application of energy to cause selective heating of the vein. The catheter is positioned within the vein to be treated, and the electrodes on the catheter are moved toward one side of the vein. RF energy is applied in a directional manner from the electrodes at the working end of the catheter to cause localized heating and corresponding shrinkage of the adjacent venous tissue, which may include commissures, leaflets and ostia. Fluoroscopy or ultrasound may be used to detect shrinkage of the vein. After treating one section of the vein, the catheter can be repositioned to place the electrodes to treat different sections of the vein until all desired venous valves are repaired and rendered functionally competent.

摘要翻译： 导管通过施加能量来引起静脉的选择性加热，将电极引入静脉中用于微创治疗静脉功能不全。 将导管定位在待治疗的静脉内，导管上的电极向静脉的一侧移动。 射频能量以定向方式从导管的工作端处的电极施加，以引起相邻静脉组织的局部加热和相应的收缩，其可以包括连合，小叶和口。 荧光透视或超声可用于检测静脉的收缩。 在治疗静脉的一部分之后，可以重新定位导管以放置电极来治疗静脉的不同部分，直到所有期望的静脉瓣被修复并且具有功能上的能力。

公开(公告)号：US6033398A

公开(公告)日：2000-03-07

申请号：US811820

申请日：1997-03-04

申请人： Brian E. Farley ,  Michael D. Laufer ,  Dawn A. Henderson ,  Douglas M. Petty ,  Mark P. Parker

发明人： Brian E. Farley ,  Michael D. Laufer ,  Dawn A. Henderson ,  Douglas M. Petty ,  Mark P. Parker

IPC分类号： A61B18/04 ,  A61B17/00 ,  A61B17/22 ,  A61B18/12 ,  A61B18/14 ,  A61B18/08

CPC分类号： A61B18/1492 ,  A61B17/00008 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00702 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

摘要： A catheter introduces electrodes in a vein for a minimally invasive treatment of venous insufficiency by the application of energy to cause selective heating of the vein. The catheter is positioned within the vein to be treated, and the electrodes on the catheter are moved toward one side of the vein. RF energy is applied in a directional manner from the electrodes at the working end of the catheter to cause localized heating and corresponding shrinkage of the adjacent venous tissue, which may include commissures, leaflets and ostia. Fluoroscopy or ultrasound may be used to detect shrinkage of the vein. After treating one section of the vein, the catheter can be repositioned to place the electrodes to treat different sections of the vein until all desired venous valves are repaired and rendered functionally competent.

摘要翻译： 导管通过施加能量来引起静脉的选择性加热，将电极引入静脉中用于微创治疗静脉功能不全。 将导管定位在待治疗的静脉内，导管上的电极向静脉的一侧移动。 射频能量以定向方式从导管的工作端处的电极施加，以引起相邻静脉组织的局部加热和相应的收缩，其可以包括连合，小叶和口。 荧光透视或超声可用于检测静脉的收缩。 在治疗静脉的一部分之后，可以重新定位导管以放置电极来治疗静脉的不同部分，直到所有期望的静脉瓣被修复并且具有功能上的能力。

公开(公告)号：US07976536B2

公开(公告)日：2011-07-12

申请号：US11280778

申请日：2005-11-16

申请人： Brian E. Farley ,  Michael D. Laufer ,  Dawn A. Henderson ,  Douglas M. Petty ,  Mark P. Parker

发明人： Brian E. Farley ,  Michael D. Laufer ,  Dawn A. Henderson ,  Douglas M. Petty ,  Mark P. Parker

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B17/00008 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00702 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

摘要： A catheter introduces electrodes in a vein for a minimally invasive treatment of venous insufficiency by the application of energy to cause selective heating of the vein. The catheter is positioned within the vein to be treated, and the electrodes on the catheter are moved toward one side of the vein. RF energy is applied in a directional manner from the electrodes at the working end of the catheter to cause localized heating and corresponding shrinkage of the adjacent venous tissue, which may include commissures, leaflets and ostia. Fluoroscopy or ultrasound may be used to detect shrinkage of the vein. After treating one section of the vein, the catheter can be repositioned to place the electrodes to treat different sections of the vein until all desired venous valves are repaired and rendered functionally competent.

摘要翻译： 导管通过施加能量来引起静脉的选择性加热，将电极引入静脉中用于微创治疗静脉功能不全。 将导管定位在待治疗的静脉内，导管上的电极向静脉的一侧移动。 射频能量以定向方式从导管的工作端处的电极施加以引起相邻静脉组织的局部加热和相应的收缩，其可以包括连合，小叶和口。 荧光透视或超声可用于检测静脉的收缩。 在治疗静脉的一部分之后，可以重新定位导管以放置电极来治疗静脉的不同部分，直到所有期望的静脉瓣被修复并且具有功能上的能力。

公开(公告)号：US06638273B1

公开(公告)日：2003-10-28

申请号：US09724248

申请日：2000-11-27

申请人： Brian E. Farley ,  Grace Y. Schulz ,  Dawn A. Henderson ,  Mark P. Parker ,  Arthur W. Zikorus ,  Gary H. Miller ,  Jay S. Daulton ,  Douglas Portnow

发明人： Brian E. Farley ,  Grace Y. Schulz ,  Dawn A. Henderson ,  Mark P. Parker ,  Arthur W. Zikorus ,  Gary H. Miller ,  Jay S. Daulton ,  Douglas Portnow

IPC分类号： A61B1804

CPC分类号： A61B18/1492 ,  A61B17/00008 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00702 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

摘要： A catheter having expandable electrodes for applying energy to a hollow anatomical structure such as a vein. When used on a vein, the catheter is useful for a minimally invasive treatment of venous insufficiency. The catheter includes conductive end rings to which the electrodes are attached, for mechanically connecting and electrically tying electrodes together to provide for a single wire electrical connection points, for transmitting energy while more evenly spacing the electrodes. Expandable arms are formed of electrically conductive material and insulated along their length except for an intermediate section that functions as the electrode. The arms are tapered to allow more room for wiring and to reduce the possibility of shorting between the ends of the arms. The catheter further includes thermocouples in the electrodes for measuring temperatures on the outer surface of the electrode. Slots are formed in the arms for mounting the thermocouples. The temperature at the hollow anatomical structure is monitored and if a rapid, large temperature decrease of short duration is noted, the power is maintained constant as a fluid flush has been detected.

摘要翻译： 具有用于向诸如静脉的中空解剖结构施加能量的可扩张电极的导管。 当静脉使用时，导管可用于静脉功能不全的微创治疗。 导管包括导电端环，电极附接到该导电端环，用于将电极机械连接并电连接在一起，以提供单线电连接点，用于在更均匀地间隔电极的同时发射能量。 可扩展臂由导电材料形成并且沿其长度绝缘，除了用作电极的中间部分之外。 臂是锥形的，以允许更多的布线空间并且减少在臂的端部之间短路的可能性。 该导管还包括用于测量电极外表面上的温度的电极中的热电偶。 插槽形成在用于安装热电偶的臂中。 监测中空解剖结构的温度，如果注意到持续时间短的快速，大的温度降低，则检测到流体冲洗时，功率保持恒定。

公开(公告)号：US06689126B1

公开(公告)日：2004-02-10

申请号：US09497278

申请日：2000-02-03

申请人： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

发明人： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

IPC分类号： A61B1804

CPC分类号： A61B18/1492 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00589 ,  A61B2018/00898 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2090/3782 ,  A61B2218/002

摘要： A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a balloon is inflated to occlude the structure before the application of energy. Where the structure is a vein, the inflated balloon obstructs blood flow and facilitates the infusion of saline, medication, or a high-impedance fluid to the vein in order to reduce the occurrence of coagulation and to improve the heating of the vein by the catheter. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

公开(公告)号：US6152899A

公开(公告)日：2000-11-28

申请号：US895850

申请日：1997-07-17

申请人： Brian E. Farley ,  Grace Y. Schulz ,  Dawn A. Henderson ,  Mark P. Parker ,  Arthur W. Zikorus ,  Gary H. Miller ,  Jay S. Daulton ,  Douglas Portnow

发明人： Brian E. Farley ,  Grace Y. Schulz ,  Dawn A. Henderson ,  Mark P. Parker ,  Arthur W. Zikorus ,  Gary H. Miller ,  Jay S. Daulton ,  Douglas Portnow

IPC分类号： A61B18/04 ,  A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/12 ,  A61B18/14 ,  A61F7/12

CPC分类号： A61B18/1492 ,  A61B17/00008 ,  A61B2017/22051 ,  A61B2017/22097 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00083 ,  A61B2018/00154 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00285 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00702 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1465 ,  A61B2018/1497

摘要： A catheter having expandable electrodes for applying energy to a hollow anatomical structure such as a vein. When used on a vein, the catheter is useful for a minimally invasive treatment of venous insufficiency. The catheter includes conductive end rings to which the electrodes are attached, for mechanically connecting and electrically tying electrodes together to provide for a single wire electrical connection points, for transmitting energy while more evenly spacing the electrodes. Expandable arms are formed of electrically conductive material and insulated along their length except for an intermediate section that functions as the electrode. The arms are tapered to allow more room for wiring and to reduce the possibility of shorting between the ends of the arms. The catheter further includes thermocouples in the electrodes for measuring temperatures on the outer surface of the electrode. Slots are formed in the arms for mounting the thermocouples. The temperature at the hollow anatomical structure is monitored and if a rapid, large temperature decrease of short duration is noted, the power is maintained constant as a fluid flush has been detected.

公开(公告)号：US07041098B2

公开(公告)日：2006-05-09

申请号：US10162057

申请日：2002-06-03

申请人： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

发明人： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00589 ,  A61B2018/00898 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2090/3782 ,  A61B2218/002

摘要： A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a balloon is inflated to occlude the structure before the application of energy. Where the structure is a vein, the inflated balloon obstructs blood flow and facilitates the infusion of saline, medication, or a high-impedance fluid to the vein in order to reduce the occurrence of coagulation and to improve the heating of the vein by the catheter. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

公开(公告)号：US06398780B1

公开(公告)日：2002-06-04

申请号：US09497099

申请日：2000-02-03

申请人： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

发明人： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

IPC分类号： A61B1739

CPC分类号： A61B18/1492 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2017/22067 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00488 ,  A61B2018/00589 ,  A61B2018/00898 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2090/3782 ,  A61B2218/002

摘要： A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a balloon is inflated to occlude the structure before the application of energy. Where the structure is a vein, the inflated balloon obstructs blood flow and facilitates the infusion of saline, medication, or a high-impedance fluid to the vein in order to reduce the occurrence of coagulation and to improve the heating of the vein by the catheter. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

公开(公告)号：US6165172A

公开(公告)日：2000-12-26

申请号：US958766

申请日：1997-10-26

申请人： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

发明人： Brian E. Farley ,  Dawn A. Henderson ,  Christopher S. Jones ,  Mark P. Parker ,  Joseph M. Tartaglia

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/14 ,  A61B18/04

CPC分类号： A61B18/1492 ,  A61B2017/00084 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002

摘要： A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with a hollow anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a balloon is inflated to occlude the structure before the application of energy. Where the structure is a vein, the inflated balloon obstructs blood flow and facilitates the infusion of saline, medication, or a high-impedance fluid to the vein in order to reduce the occurrence of coagulation and to improve the heating of the vein by the catheter. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

公开(公告)号：US08679110B2

公开(公告)日：2014-03-25

申请号：US12181277

申请日：2008-07-28

申请人： Arthur W. Zikorus ,  Mark P. Parker ,  Christopher S. Jones ,  Douglas M. Petty ,  Brian E. Farley ,  Joseph M. Tartaglia

发明人： Arthur W. Zikorus ,  Mark P. Parker ,  Christopher S. Jones ,  Douglas M. Petty ,  Brian E. Farley ,  Joseph M. Tartaglia

IPC分类号： A61F5/56 ,  A61B18/18 ,  A61B18/20

CPC分类号： A61B18/1492 ,  A61B2017/00084 ,  A61B2017/22038 ,  A61B2017/22051 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1475 ,  A61B2090/3782 ,  A61B2218/002

摘要： A catheter includes a plurality of primary leads to deliver energy for ligating a hollow anatomical structure. Each of the primary leads includes an electrode located at the working end of the catheter. Separation is maintained between the primary leads such that each primary lead can individually receive power of selected polarity. The primary leads are constructed to expand outwardly to place the electrodes into apposition with an anatomical structure. High frequency energy can be applied from the leads to create a heating effect in the surrounding tissue of the anatomical structure. The diameter of the hollow anatomical structure is reduced by the heating effect, and the electrodes of the primary leads are moved closer to one another. Where the hollow anatomical structure is a vein, energy is applied until the diameter of the vein is reduced to the point where the vein is occluded. In one embodiment, a secondary lead is surrounded by the primary leads, and extends beyond the primary leads. The secondary lead includes an electrode at the working end of the catheter. The secondary lead can have a polarity opposite to the polarity of the primary leads in a bipolar configuration. The polarity of the leads can be switched and the catheter can be moved during treatment to ligate an extended length of the vein. The catheter can include a lumen to accommodate a guide wire or to allow fluid delivery.

摘要翻译： 导管包括多个主引线以传递用于结扎中空解剖结构的能量。 每个主引线包括位于导管工作端的电极。 在主引线之间保持分离，使得每个主引线可以分别接收所选极性的功率。 主引线被构造成向外扩展以使电极与解剖结构相配合。 可以从引线施加高频能量以在解剖结构的周围组织中产生加热效果。 中空解剖结构的直径由于加热效应而降低，并且主引线的电极彼此靠近地移动。 当中空解剖结构为静脉时，施加能量直到静脉的直径减小到静脉闭塞的位置。 在一个实施例中，次级引线被主引线包围，并且延伸超出主引线。 次级引线包括在导管的工作端的电极。 次级引线可以具有与双极配置中的主引线的极性相反的极性。 可以切换引线的极性，并且可以在治疗期间移动导管以连接延长的静脉长度。 导管可以包括用于容纳导丝或者允许流体输送的内腔。