公开(公告)号：US20200323665A1

公开(公告)日：2020-10-15

申请号：US15929239

申请日：2020-03-05

申请人： Brigham Young University

发明人： Anton Bowden ,  Brian Jensen ,  Kristopher Jones ,  Darrell Skousen

IPC分类号： A61F2/915 ,  A61F2/82 ,  B29C59/00 ,  A61L31/14 ,  A61L31/12 ,  A61F2/86 ,  A61F2/844

摘要： As detailed herein, a biocompatible apparatus comprises a porous material comprising ceramic nanotubes bound together with a filler material. The proportion of the filler material may be selected to provide porosity for the porous material that is biocompatible, and the porous material may be shaped to provide a compliant biomedical device. In one embodiment, the compliant biomedical device is a stent such as intravascular stent. A method for fabricating a biocompatible device is also described herein. The method may include growing ceramic nanotubes on a substrate, infiltrating the ceramic nanotubes with a filler material to provide a porous material having a porosity that is biocompatible, and removing the porous material from the substrate to provide a biocompatible ceramic device. The method may also include coating the biocompatible ceramic device with a drug-eluting material.

公开(公告)号：US20200330250A1

公开(公告)日：2020-10-22

申请号：US15999254

申请日：2017-02-17

申请人： Brigham Young University

发明人： Darrell Skousen ,  Anton E. Bowden

IPC分类号： A61F2/915

摘要： A multi-stage stent including a stent body and a bio-erodible material is provided. The stent body can be compressed in an initial state and the bio-erodible material can be coupled to the stent body in a configuration that holds the stent body in an expanded first state, following a first stage expansion from the initial state upon deployment of the stent body. Upon erosion of the bio-erodible material the stent body is released from the first state to expand further in a second stage expansion to a second state.

公开(公告)号：US20140094900A1

公开(公告)日：2014-04-03

申请号：US14043787

申请日：2013-10-01

申请人： Brigham Young University

发明人： Anton Bowden ,  Brian Jensen ,  Kristopher Jones ,  Darrell Skousen

IPC分类号： A61F2/82 ,  B29C59/00

摘要： As detailed herein, a biocompatible apparatus comprises a porous material comprising ceramic nanotubes bound together with a filler material. The proportion of the filler material may be selected to provide porosity for the porous material that is biocompatible, and the porous material may be shaped to provide a compliant biomedical device. In one embodiment, the compliant biomedical device is a stent such as intravascular stent. A method for fabricating a biocompatible device is also described herein. The method may include growing ceramic nanotubes on a substrate, infiltrating the ceramic nanotubes with a filler material to provide a porous material having a porosity that is biocompatible, and removing the porous material from the substrate to provide a biocompatible ceramic device. The method may also include coating the biocompatible ceramic device with a drug-eluting material.

摘要翻译： 如本文详细描述的，生物相容性装置包括多孔材料，其包含与填充材料结合在一起的陶瓷纳米管。 可以选择填充材料的比例以提供生物相容性的多孔材料的孔隙率，并且多孔材料可以被成形以提供顺应性生物医学装置。 在一个实施例中，顺应性生物医学装置是诸如血管内支架的支架。 本文还描述了制造生物相容性装置的方法。 该方法可以包括在衬底上生长陶瓷纳米管，用填充材料渗透陶瓷纳米管，以提供具有生物相容性的孔隙率的多孔材料，以及从衬底去除多孔材料以提供生物相容性陶瓷器件。 该方法还可以包括用药物洗脱材料涂覆生物相容性陶瓷器件。