公开(公告)号：US20220331315A1

公开(公告)日：2022-10-20

申请号：US17639481

申请日：2020-09-18

申请人： Bristol-Myers Squibb Company

发明人： Sherif Ibrahim Farag Badawy ,  Jonathan R. Brown ,  Candice Y. Choi ,  Christoph Gesenberg ,  Vivienne Gray ,  John Wynne Jones ,  Umesh Kestur ,  Balvinder S. Vig ,  Xiaotian S. Yin ,  Christopher A. Zordan ,  Corey Bloom ,  lan Yates

IPC分类号： A61K31/501 ,  A61K9/00 ,  A61K45/06 ,  A61K9/20 ,  A61K9/28

摘要： Stable and bioavailable formulations and dosage forms comprising a dispersion (e.g., spray-dried dispersion) of solid amorphous 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide (Formula (I); BMS-986165) in a solid polymer matrix are provided for the treatment of auto-immune and auto-inflammatory diseases such as an inflammatory bowel disease (IBD) and psoriasis.

公开(公告)号：US20230255964A1

公开(公告)日：2023-08-17

申请号：US17639489

申请日：2020-09-18

申请人： Bristol-Myers Squibb Company

发明人： Sherif Ibrahim Farag Badawy ,  Jonathan R. Brown ,  Candice Y. Choi ,  Christoph Gesenberg ,  Vivienne Gary ,  John Wynne Jones ,  Umesh Kestur ,  Balvinder S. Vig ,  Xiaotian S. Yin ,  Christopher A. Zordan ,  Corey Bloom ,  Ian Yates

IPC分类号： A61K31/501 ,  A61K9/20

CPC分类号： A61K31/501 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2054

摘要： Stable and bioavailable extended-release formulations and dosage forms comprising a dispersion (e.g., spray-dried dispersion) of solid amorphous 6-(cyclopropaneamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyrid azine-3-carboxamide (Formula (I); BMS-986165) in a solid polymer matrix are provided for the treatment of auto-immune and auto-inflammatory diseases such as an inflammatory bowel disease (IBD) and psoriasis.