公开(公告)号：US20220169742A1

公开(公告)日：2022-06-02

申请号：US17670223

申请日：2022-02-11

Applicant: Bristol-Myers Squibb Company

Inventor： Aaron YAMNIUK ,  Mary STRUTHERS ,  Stanley R. KRYSTEK, Jr. ,  Akbar NAYEEM ,  Ginger RAKESTRAW

IPC: C07K16/28 ,  A61K47/68 ,  A61K39/395 ,  C07K16/46 ,  A61P37/00

Abstract: The disclosure provides for antibodies that bind CD40, including a humanized antibody. The antibodies bind CD40 and do not exhibit CD40 agonist activity. The antibodies may comprise a modified IgG1 Fc domain, and exhibit minimal activation of immature dendritic cells. Compositions comprising antibodies, methods of use for treatment of diseases involving CD40 activity, and use in the preparation of a medicament for treatment of a disease involving CD40 activity are provided.