公开(公告)号：US20180142023A1

公开(公告)日：2018-05-24

申请号：US15870121

申请日：2018-01-12

申请人： Bristol-Myers Squibb Company ,  Domantis Limited

发明人： Murray McKinnon ,  Steven G. Nadler ,  Suzanne J. Suchard ,  Brendan Classon ,  Steve Holmes ,  Olga Ignatovich ,  Christopher Plummer ,  Steve Grant

IPC分类号： C07K16/28 ,  A61K45/06 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/73

摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.

公开(公告)号：US09908937B2

公开(公告)日：2018-03-06

申请号：US14740709

申请日：2015-06-16

申请人： Bristol-Myers Squibb Company ,  Domantis Limited

发明人： Murray McKinnon ,  Steven G. Nadler ,  Suzanne J. Suchard ,  Brendan Classon ,  Steve Holmes ,  Olga Ignatovich ,  Christopher Plummer ,  Steve Grant

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/73

摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.

公开(公告)号：US12012452B2

公开(公告)日：2024-06-18

申请号：US17086565

申请日：2020-11-02

申请人： Bristol-Myers Squibb Company ,  Domantis Limited

发明人： Murray McKinnon ,  Steven G. Nadler ,  Suzanne J. Suchard ,  Brendan Classon ,  Steve Holmes ,  Olga Ignatovich ,  Christopher Plummer ,  Steve Grant

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P37/06 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2896 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/73

摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.

公开(公告)号：US20210047414A1

公开(公告)日：2021-02-18

申请号：US17086565

申请日：2020-11-02

申请人： Bristol-Myers Squibb Company ,  Domantis Limited

发明人： Murray McKinnon ,  Steven G. Nadler ,  Suzanne J. Suchard ,  Brendan Classon ,  Steve Holmes ,  Olga Ignatovich ,  Christopher Plummer ,  Steve Grant

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06

摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.

公开(公告)号：US10919965B2

公开(公告)日：2021-02-16

申请号：US15870121

申请日：2018-01-12

申请人： Bristol-Myers Squibb Company ,  Domantis Limited

发明人： Murray McKinnon ,  Steven G. Nadler ,  Suzanne J. Suchard ,  Brendan Classon ,  Steve Holmes ,  Olga Ignatovich ,  Christopher Plummer ,  Steve Grant

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.

公开(公告)号：US20150299321A1

公开(公告)日：2015-10-22

申请号：US14740709

申请日：2015-06-16

申请人： Bristol-Myers Squibb Company ,  Domantis Ltd.

发明人： Murray McKinnon ,  Steven G. Nadler ,  Suzanne J. Suchard ,  Brendan Classon ,  Steve Holmes ,  Olga Ignatovich ,  Christopher Plummer ,  Steve Grant

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC分类号： C07K16/2818 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/31 ,  C07K2317/569 ,  C07K2317/73

摘要： Disclosed are domain antibodies that monovalently bind CD28. Domain antibodies that are monovalent for binding of CD28 can inhibit CD28 activity. In one aspect, a domain antibody consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD28, in an aspect, without substantially agonizing CD28 activity. In another aspect, the domain antibody is a human domain antibody. The disclosure further encompasses methods of antagonizing CD80 and/or CD86 interactions with CD28 in an individual and methods of treating diseases or disorders involving CD80 and/or CD86 interactions with CD28, the methods involving administering a domain antibody to the individual.

摘要翻译： 公开了单价结合CD28的结构域抗体。 对CD28结合而言是单价的域抗体可抑制CD28活性。 在一个方面，结构域抗体由一个方面组成或包含单个免疫球蛋白可变区，其特异性结合并拮抗CD28的活性，一方面，没有实质上激动的CD28活性。 另一方面，结构域抗体是人结构域抗体。 本公开还包括在个体中拮抗CD80和/或CD86相互作用的方法以及涉及与CD28相互作用的CD80和/或CD86相互作用的疾病或病症的方法，所述方法涉及对个体施用结构域抗体。