公开(公告)号：US11447775B2

公开(公告)日：2022-09-20

申请号：US16961624

申请日：2019-01-11

申请人： Bristol-Myers Squibb Company ,  Roche Innovation Center Copenhagen A/S

发明人： Richard E. Olson ,  Angela M. Cacace ,  Jere E. Meredith, Jr. ,  Nino Devidze ,  James K. Loy ,  Carl J. Baldick ,  Annapurna Pendri ,  Ivar M. McDonald ,  Peter Hagedorn ,  Marianne Lerbech Jensen

IPC分类号： C07H21/04 ,  C12N15/113

摘要： The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.

公开(公告)号：US11359197B2

公开(公告)日：2022-06-14

申请号：US17165841

申请日：2021-02-02

申请人： Bristol-Myers Squibb Company ,  Roche Innovation Center Copenhagen A/S

发明人： Richard E. Olson ,  Angela M. Cacace ,  Jere E. Meredith, Jr. ,  Nino Devidze ,  James K. Loy ,  Carl J. Baldick ,  Annapurna Pendri ,  Ivar M. McDonald ,  Peter Hagedorn ,  Marianne Lerbech Jensen

IPC分类号： C12N15/113

摘要： The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.