专利检索 ap:("Bruker BioSpin GmbH") AND inv:"Kimberly Colson" 第 1 页

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发明授权
Method and device for the automatable determination of the limit of quantification and the relative error when quantifying the concentration of a substance to be investigated in a test sample 有权

公开(公告)号：US10330613B2

公开(公告)日：2019-06-25

申请号：US15297637

申请日：2016-10-19

申请人： Bruker BioSpin GmbH

发明人： Christian Fischer , Carsten Kuhl , Kimberly Colson

IPC分类号： G01N24/08 , G01R33/46

摘要： A spectroscopic method for calculating a limit of quantification and a relative error includes: 1. selecting an error function F(C); 2. providing a blank spectrum; 3. recording a reference spectrum with a signal content of the substance being investigated; 4. determining start concentrations; 5.a. multiplying the reference spectrum with the signal content of the substance by a factor; 5.b. adding the resulting spectrum to the blank spectrum and determining the corresponding concentration of the substance and calculating the corresponding relative error; 6. iteratively adapting parameters of the selected error function F(C): recording a measurement spectrum of the test sample and determining the concentration of the substance being investigated using 5.b. and comparing with the calculated limit of quantification and calculating the relative error by applying the error function from step 6.