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1.发明授权Process for the preparation of crystalline forms of agomelatine and novel polymorph thereof 有权制备agomelatine结晶形式的方法及其新型多晶型物公开(公告)号：US09024068B2
公开(公告)日：2015-05-05
申请号：US14126731
申请日：2011-12-29
IPC分类号： C07C231/12 , C07C231/24
CPC分类号： C07C231/12 , C07C231/24 , C07C233/18
摘要： The invention concerns a new process for the preparation of crystalline form of agomelatine from a solution of agomelatine in a solvent, characterized in that the agomelatine is crystallized by instantaneous precipitation from said solution, at a temperature equal to or below −10° C.
摘要翻译： 本发明涉及一种从阿米苏定在溶剂中制备结晶形式的agomelatine的新方法，其特征在于，在等于或低于-10℃的温度下，从所述溶液中瞬间沉淀，所述agomelatine结晶。
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2.发明申请PROCESS FOR THE PREPARATION OF CRYSTALLINE FORMS OF AGOMELATINE AND NOVEL POLYMORPH THEREOF 有权制备聚酰胺和其新型聚合物的结晶形式的方法公开(公告)号：US20140221690A1
公开(公告)日：2014-08-07
申请号：US14126731
申请日：2011-12-29
IPC分类号： C07C231/12
CPC分类号： C07C231/12 , C07C231/24 , C07C233/18
摘要： The invention concerns a new process for the preparation of two crystalline forms of agomelatine, in particular a process for preparation of form I and a new form of agomelatine, here called form VII.
摘要翻译： 本发明涉及一种用于制备两种结晶形式的agomelatine的新方法，特别是制备形式I的方法和一种新形式的agomelatine，这里称为形式VII。
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