公开(公告)号：US20130012714A1

公开(公告)日：2013-01-10

申请号：US13578078

申请日：2011-02-04

申请人： Buchi Reddy Reguri ,  Sampath kumar Upparapalli ,  Thirumurugan Kunchithapatham ,  Sabarinathan Natarajan ,  Thiyagarajan Sambashivam ,  Suresh Munuswamy ,  Susi Swaminathan

发明人： Buchi Reddy Reguri ,  Sampath kumar Upparapalli ,  Thirumurugan Kunchithapatham ,  Sabarinathan Natarajan ,  Thiyagarajan Sambashivam ,  Suresh Munuswamy ,  Susi Swaminathan

IPC分类号： C07D401/12

CPC分类号： C07D401/12 ,  C07D235/28

摘要： The present invention provides novel solvate of dexlansoprazole (or R-lansoprazole), particularly diol solvate and its hydrate form of dexlansoprazole (or R-lansoprazole) which is chemically known as (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole compound of the formula (I), as well as processes for the preparation thereof. The said solvates are useful in the preparation of dexlansoprazole with enhanced chiral purity and better HPLC purity with less sulphone impurity content.

摘要翻译： 本发明提供了右旋兰索唑（或R-兰索拉唑）特别是二醇溶剂合物及其水合物形式的右兰索拉唑（或R-兰索拉唑）的新型溶剂化物，其化学上称为（R）-2 - [[[3-甲基-4- （2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] -1H-苯并咪唑化合物及其制备方法。 所述溶剂合物可用于制备具有增强的手性纯度的右兰索拉唑和更好的HPLC纯度，较少的砜含量。