公开(公告)号：US20100203612A1

公开(公告)日：2010-08-12

申请号：US12704877

申请日：2010-02-12

申请人： Byeong Cheol AHN ,  Jae Tae LEE ,  Je Yeol CHO ,  Jung Soo YU ,  Yong Jin LEE ,  Sang Woo LEE ,  You La LEE

发明人： Byeong Cheol AHN ,  Jae Tae LEE ,  Je Yeol CHO ,  Jung Soo YU ,  Yong Jin LEE ,  Sang Woo LEE ,  You La LEE

IPC分类号： C12N9/00 ,  C07K7/08

CPC分类号： C07K7/08 ,  A61K38/00

摘要： A specific targeting peptide binding to glypican-3 can specifically binds to glypican-3 overexpressed in carcinoma cells and includes an amino acid sequence represented by SEQ ID No. 1 or some thereof. Glypican-3 is overexpressed in malignant tumors including hepatocellular carcinoma, melanoma, germ cell tumor, etc., and may be targeted in diagnosis and treatment of tumors by marking the targeting peptide. A diagnosis using the targeting peptide may detect even small tumors more accurately than conventional methods. A treatment method using the targeting peptide may remove only carcinoma cells without harming other normal tissues.

摘要翻译： 结合磷脂酰肌醇蛋白聚糖-3的特异性靶向肽可以特异性地结合癌细胞中过表达的磷脂酰肌醇蛋白聚糖-3，并且包括由SEQ ID No.1或其部分表示的氨基酸序列。 胰蛋白聚糖-3在恶性肿瘤中过表达，包括肝细胞癌，黑素瘤，生殖细胞肿瘤等，并可通过标记靶向肽来靶向肿瘤的诊断和治疗。 使用靶向肽的诊断可以比常规方法更准确地检测到甚至小的肿瘤。 使用靶向肽的治疗方法可以仅去除癌细胞而不伤害其他正常组织。