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1.
公开(公告)号:US5952336A
公开(公告)日:1999-09-14
申请号:US792611
申请日:1997-01-31
申请人: C. Edgar Cook , Joseph M. Jump , Pingsheng Zhang , John R. Stephens , Patricia A. Fail , Yue-Wei Lee , Mansukh C. Wani
发明人: C. Edgar Cook , Joseph M. Jump , Pingsheng Zhang , John R. Stephens , Patricia A. Fail , Yue-Wei Lee , Mansukh C. Wani
IPC分类号: A61K51/00 , A61P15/16 , C07D221/16 , A61K31/44
CPC分类号: C07D221/16
摘要: Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R.sup.1 is C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions; R.sup.4 is halogen; mixtures of said compound and acid addition salts thereof exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.
摘要翻译: 具有下式的六氢茚基化合物和其中R 1为C 1-6烷基的相对立体化学; R2是氢或C1-6烷基; R3是羧基或在哺乳动物生理条件下代谢成羧基的基团; R4是卤素; 所述化合物及其酸加成盐的混合物显示出有效的抗生殖活性,并且可用于抑制哺乳动物精子发生的方法。
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2.
公开(公告)号:US5319084A
公开(公告)日:1994-06-07
申请号:US106655
申请日:1993-08-16
IPC分类号: C07D221/16 , A01N43/42 , A61K31/44
CPC分类号: C07D221/16
摘要: Hexahydroindenopyridine compounds having the following formula and relative stereochemistry ##STR1## where R.sup.1 is C.sub.1-6 alkyl, R.sup.2 is hydrogen or C.sub.1-6 alkyl and R.sup.3 is carboxyl or a group which is metabolized to a carboxyl group under mammalian physiological conditions exhibit potent antispermatogenic activity and are useful in a method of inhibiting spermatogenesis in mammals.
摘要翻译: 其中R 1为C 1-6烷基,R 2为氢或C 1-6烷基,R 3为羧基或在哺乳动物生理条件下被代谢为羧基的基团,具有下式的相关立体化学性质和相对立体化学性质表现出有效的抗生殖活性 并且可用于抑制哺乳动物精子发生的方法。
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