公开(公告)号：US20180311241A1

公开(公告)日：2018-11-01

申请号：US15771334

申请日：2016-10-20

申请人： CADILA HEALTHCARE LIMITED

发明人： Mukul JAIN ,  Kaushik BANERJEE ,  Amit JOHARAPURKAR ,  Arti PANDYA ,  Vishal PATEL

IPC分类号： A61K31/513

CPC分类号： A61K31/506 ,  A61K31/216 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention describes a synergistic composition comprising of Fimasartan or pharmaceutically effective salts thereof and a NEP inhibitor or pharmaceutically effective salts thereof for the treatment of cardiovascular and related disease. The present invention is directed to a synergistic combination comprising combinations of Fimasartan or suitable pharmaceutically effective salts thereof and a NEP inhibitor or pharmaceutically effective salts thereof in a single unit pharmaceutical composition. The present invention is further directed to combinations of Fimasartan or a pharmaceutically effective salt thereof and a NEP inhibitor or a pharmaceutically effective salt thereof. The invention also relates to combining separate pharmaceutical compositions of Fimasartan and a NEP inhibitor in kit form. The invention is further related to methods of preparing such pharmaceutical composition in separate in either a kit form containing both the active agents and methods of treating a subject with the same.