公开(公告)号：US20150094697A1

公开(公告)日：2015-04-02

申请号：US14562579

申请日：2014-12-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Derek Rinderknecht ,  Hesham Azizgolshani ,  Morteza Gharib

IPC: A61M5/142

CPC classification number: A61M5/14276 ,  A61M5/14224 ,  A61M37/00 ,  A61M2205/8206 ,  A61M2205/8212 ,  A61M2205/8243 ,  A61M2207/00 ,  A61M2210/0612 ,  A61M2210/0662 ,  A61M2210/0693 ,  G01F11/08

Abstract: Described herein are systems, devices, and methods for the delivery of substances to, or the sampling of substances from, a patient using a portable and preferably implantable device. The substances introduced to and/or taken from the patient are preferably fluidic and are driven by a miniature pump, such as a microimpedance pump. A number of design variations are explicitly and implicitly described, such as the use of multiple pumps and multiple reservoirs for containing medicaments. Methods of manufacture of these systems and devices are also described, for instance, using molding, micromachining, or lithographic processes.

Abstract translation: 本文描述了用于使用便携式和优选可植入装置向患者输送物质或从其中取样物质的系统，装置和方法。 引入和/或从患者取出的物质优选是流体性的，并且由微型泵例如微阻抗泵驱动。 明确和隐含地描述了许多设计变化，例如使用多个泵和多个储存器来容纳药物。 还描述了这些系统和装置的制造方法，例如使用成型，微加工或光刻工艺。

公开(公告)号：US20140171912A1

公开(公告)日：2014-06-19

申请号：US14109662

申请日：2013-12-17

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Morteza Gharib ,  Hesham Azizgolshani

IPC: A61M25/10

CPC classification number: A61M25/104 ,  A61M2025/105 ,  A61M2025/1075 ,  A61M2025/1084

Abstract: Systems, devices, and methods are provided for drug-eluting angioplasty balloons. An underlying balloon core member is protected by a core-screen from mechanical and flow shear forces during delivery. Inflation of the balloon opens the screen and pores in the screen permitting drug transfer and absorption. Upon deflation, the screen can be compressed and withdrawn with the balloon.

Abstract translation: 提供了用于药物洗脱血管成形术气球的系统，装置和方法。 潜在的气球芯部件在输送过程中受到核心屏幕的机械和流动剪切力的保护。 球囊的通气打开屏幕和屏幕中的孔，允许药物转移和吸收。 放气时，可以用气球压缩和撤回屏幕。