公开(公告)号：US10955496B2

公开(公告)日：2021-03-23

申请号：US15663600

申请日：2017-07-28

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： George J. Lu ,  Mikhail G. Shapiro ,  Arash Farhadi ,  Jerzy O. Szablowski

IPC: G01R33/28 ,  A61B5/055 ,  G01R33/50 ,  A61B8/08 ,  G01R33/48 ,  G01R33/56 ,  A61B8/00

Abstract: Gas vesicle protein structures and related compositions, methods, and systems for singleplexed and/or multiplexed magnetic resonance imaging of a target site alone or in combination with ultrasound are described, in which the gas vesicle protein structures provide contrast for the imaging.

公开(公告)号：US20230047753A1

公开(公告)日：2023-02-16

申请号：US17814384

申请日：2022-07-22

Applicant: California Institute of Technology

Inventor： Jerzy O. Szablowski ,  Hongyi Li ,  John E. Heath ,  Mikhail G. Shapiro

IPC: C12N15/861

Abstract: Disclosed herein include adeno-associated virus (AAV) acoustic targeting peptides. An AAV comprising the AAV acoustic targeting peptide can exhibit increased transduction at site(s) of focused ultrasound blood-brain barrier opening (FUS-BBBO), increased neuronal tropism, and diminished transduction of peripheral organs. Disclosed herein include recombinant adeno-associated virus (rAAV) comprising an AAV acoustic targeting peptide disclosed herein. Also provided herein include methods of delivering an agent to one or more target brain region(s) of a subject.