公开(公告)号：US20190209665A1

公开(公告)日：2019-07-11

申请号：US16334446

申请日：2017-09-19

申请人： CAMBRIDGE INNOVATION TECHNOLOGIE CONSULTING LIMITED

发明人： Stefano PLUCHINO ,  Christian FREZZA ,  Edoardo GAUDE ,  Tommaso LEONARDI ,  Nunzio IRACI

IPC分类号： A61K38/50 ,  C12N9/82 ,  A61K47/69 ,  A61K38/48 ,  C12N15/86 ,  A61P35/02 ,  A61P1/16 ,  C12N15/70

CPC分类号： A61K38/50 ,  A61K35/12 ,  A61K35/30 ,  A61K38/00 ,  A61K38/48 ,  A61K47/69 ,  A61P1/16 ,  A61P35/02 ,  C12N9/485 ,  C12N9/82 ,  C12N15/70 ,  C12N15/86 ,  C12Y304/19005 ,  C12Y305/01001

摘要： The invention relates to a human asparaginase comprising an amino acid sequence that is at least 90% identical to the amino acid sequence depicted in Figure, for use as a medicament. Said asparaginase was found to lack intrinsic glutaminase activity. The invention further relates to a membraneous particle comprising said asparaginase, and to a pharmaceutical composition comprising said asparaginase and a pharmaceutically acceptable excipient.