公开(公告)号：US10344017B2

公开(公告)日：2019-07-09

申请号：US15512661

申请日：2015-09-18

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Tristan Reuillon ,  Duncan Miller ,  Stephanie Myers ,  Lauren Molyneux ,  Celine Cano ,  Ian Hardcastle ,  Roger Griffin ,  Laurent Rigoreau ,  Bernard Golding ,  Martin Noble

IPC: A61P35/00 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D413/12 ,  C07D413/14

Abstract: The invention provides compounds of formula (I) or a tautomer, stereoisomer, N-oxide, pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the prophylaxis or treatment of a disease state or condition mediated by ERK5, in particular cancers.