公开(公告)号：US20230110588A1

公开(公告)日：2023-04-13

申请号：US17721455

申请日：2022-04-15

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Lian Ni LEE ,  Senthil CHINNAKANNAN ,  Paul KLENERMAN

IPC: C12N15/86 ,  A61P35/00 ,  A61K45/06 ,  A61K38/47 ,  A61K38/17

Abstract: The present invention relates to an adenoviral vector or adeno-associated virus vector comprising a nucleotide sequence encoding a single cancer specific CD8+ T cell epitope, wherein the vector is capable of inducing an inflating memory CD8+ T cell response wherein said vector does not comprise a nucleic acid encoding further cancer specific T cell epitopes. It also relates to methods and uses of the vector.

公开(公告)号：US20240401075A1

公开(公告)日：2024-12-05

申请号：US18418855

申请日：2024-01-22

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Lian Ni LEE ,  Senthil CHINNAKANNAN ,  Paul KLENERMAN

IPC: C12N15/86 ,  A61K38/17 ,  A61K38/47 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00

Abstract: The present invention relates to an adenoviral vector or adeno-associated virus vector comprising a nucleotide sequence encoding a single cancer specific CD8+ T cell epitope, wherein the vector is capable of inducing an inflating memory CD8+ T cell response wherein said vector does not comprise a nucleic acid encoding further cancer specific T cell epitopes. It also relates to methods and uses of the vector.