公开(公告)号：US10414763B2

公开(公告)日：2019-09-17

申请号：US14668022

申请日：2015-03-25

Applicant: CANCER RESEARCH TECHNOLOGY LIMITED

Inventor： Bruce D. Dorsey ,  Benjamin J. Dugan ,  Katherine M. Fowler ,  Robert L. Hudkins ,  Eugen F. Mesaros ,  Nathaniel J T Monck ,  Emma L. Morris ,  Ikeoluwa Olowoye ,  Gregory R. Ott ,  Gregoire A. Pave ,  Jonathan R. A. Roffey ,  Christelle N. Soudy ,  Craig A. Zificsak ,  Allison L. Zulli

IPC: C07D471/04 ,  C07D519/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61K31/437

Abstract: The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disorders. Compositions comprising a compound of Formula (I) and/or a salt thereof are also provided.