公开(公告)号：US12299780B2

公开(公告)日：2025-05-13

申请号：US17237975

申请日：2021-04-22

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Peng Peng ,  Yi Qiang ,  Wenyuan Qi ,  Xiaoli Li ,  Li Yang

IPC: G06T7/00 ,  A61B6/03 ,  G06T11/00

Abstract: An apparatus for reconstructing a positron emission tomography (PET) image, comprising processing circuitry configured to extract, from raw data obtained from a PET scanner, energy data and timing data associated with a plurality of annihilation events, the extracted energy data and the extracted timing data for each annihilation event corresponding to interactions between each of a pair of gamma rays generated by each annihilation event and one or more gamma ray detectors of the PET scanner, classify each annihilation event based on respective extracted energy data and respective extracted timing data, determine, for each annihilation event and based on a calculated timing resolution of the annihilation event, a width of a time-of-flight kernel, and reconstruct, by processing circuitry, the PET image based on the obtained raw data from the PET scanner and the determined width of the time-of-flight kernel associated with each annihilation event.

公开(公告)号：US11982779B2

公开(公告)日：2024-05-14

申请号：US17230372

申请日：2021-04-14

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Wenyuan Qi ,  Yi Qiang ,  Peng Peng ,  Evren Asma ,  Jeffrey Kolthammer

IPC: G01T1/29 ,  G01T1/202

CPC classification number: G01T1/2907 ,  G01T1/202 ,  G01T1/2985

Abstract: A guided pairing method includes generating a singles list by detecting a plurality of singles at a plurality of detector elements in a detector array, the plurality of singles falling within a plurality of detection windows; for each detection window of the plurality of detection windows in the singles list having exactly two singles of the plurality of singles, determining the line of responses (LORs) for each of the two singles of the plurality of singles; for each detection window of the plurality of detection windows in the singles list having more than two singles of the plurality of singles, determining all coincidences possible based on the more than two singles; generating a weight for said each coincidence of the coincidences based on the determined LORs for said each of the two singles of the plurality of singles; and pairing the more than two singles based on the generated weight for said each coincidence of the coincidences.

公开(公告)号：US11707243B2

公开(公告)日：2023-07-25

申请号：US17230499

申请日：2021-04-14

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Liang Cai ,  Wenyuan Qi ,  Xiaochun Lai ,  Peng Peng

IPC: A61B6/00 ,  G01T1/24 ,  G01T1/172 ,  A61B6/03

CPC classification number: A61B6/5205 ,  A61B6/037 ,  G01T1/172 ,  G01T1/248 ,  G01T1/249

Abstract: Multiple interactions, such as Compton scattering, inside a PET detector are used to predict an incident photon's direction for identifying true coincidence events versus scatter/random coincidence events by creating a cone shaped shell projection defining a range of possible flight directions for the incident photon. The disclosed techniques can be used as prior information to improve the image reconstruction process. The disclosed techniques can be implemented in a LYSO/SiPM-based layer stacked detector, which can precisely register multiple interactions' 3D position.

公开(公告)号：US11573339B2

公开(公告)日：2023-02-07

申请号：US16907972

申请日：2020-06-22

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Xiaoli Li ,  Yi Qiang ,  Kent C. Burr ,  Peng Peng

IPC: G01T7/00 ,  G01T1/29 ,  A61B6/00 ,  A61B6/03

Abstract: A method and system for providing improved timing calibration information for use with apparatuses performing Time of Flight Positron Emission Tomography scans. Relative timing offset, including timing walk, within a set of processing units in the scanner are obtained and corrected using a stationary limited extent positron-emitting source, and timing offset between the set of processing units is calibrated using an internal radiation source, for performing calibration.

公开(公告)号：US12159330B2

公开(公告)日：2024-12-03

申请号：US17674063

申请日：2022-02-17

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Wenyuan Qi ,  Qiang Yi ,  Evren Asma ,  Li Yang ,  Peng Peng

IPC: G06T11/00 ,  A61B6/00 ,  A61B6/03 ,  G01T1/29

Abstract: Upon receiving list-mode data by detecting radiation emitted from a radiation source positioned with a field of view of a medical imaging scanner, each photon included in the list-mode data can be classified according to one or more interaction properties, such as energy or number of crystals interacted with. Grouped pairs of photons can be generated based on the classifying, and a corresponding interaction-property-specific correction kernel (e.g., a corresponding interaction-property-specific point spread function correction kernel) can be selected for each group. Corresponding interaction-property-specific correction kernels can then be utilized to generate higher quality images.

公开(公告)号：US11835669B2

公开(公告)日：2023-12-05

申请号：US17557710

申请日：2021-12-21

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Wenyuan Qi ,  Yi Qiang ,  Evren Asma ,  Xiaoli Li ,  Li Yang ,  Peng Peng ,  Jeffrey Kolthammer

IPC: G01T1/29

CPC classification number: G01T1/2985

Abstract: A method of normalizing detector elements in an imaging system is described herein. The method includes a line source that is easier to handle for a user, and decouples the normalization of the detector elements into a transaxial domain and an axial domain in order to isolate errors due to positioning of the line source. Additional simulations are performed to augment the real scanner normalization. A simulation of a simulated line source closely matching the real line source can be performed to isolate errors due to physical properties of the crystals and position of the crystals in the system, wherein the simulated detector crystals are otherwise modeled uniformly. A simulation of a simulated cylinder source can be performed to determine errors due to other effects stemming from gaps between the detector crystals.

公开(公告)号：US11249206B2

公开(公告)日：2022-02-15

申请号：US16866993

申请日：2020-05-05

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Wenyuan Qi ,  Yi Qiang ,  Evren Asma ,  Xiaoli Li ,  Li Yang ,  Peng Peng ,  Jeffrey Kolthammer

IPC: G01T1/29

Abstract: A method of normalizing detector elements in an imaging system is described herein. The method includes a line source that is easier to handle for a user, and decouples the normalization of the detector elements into a transaxial domain and an axial domain in order to isolate errors due to positioning of the line source. Additional simulations are performed to augment the real scanner normalization. A simulation of a simulated line source closely matching the real line source can be performed to isolate errors due to physical properties of the crystals and position of the crystals in the system, wherein the simulated detector crystals are otherwise modeled uniformly. A simulation of a simulated cylinder source can be performed to determine errors due to other effects stemming from gaps between the detector crystals.

公开(公告)号：US10451748B1

公开(公告)日：2019-10-22

申请号：US16211072

申请日：2018-12-05

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Yi Qiang ,  Steve Ross ,  Peng Peng

IPC: G01T1/24 ,  G01T1/20 ,  H01L27/146 ,  G01T1/208

Abstract: A method and an apparatus are provided for using a capacitor chain to perform charge sharing and Anger logic to determine, for charge pulses arising from gamma-ray detection, a row position along an array of scintillation-based gamma-ray detectors. Further, high-pass filters configured at the ends of the capacitor chain perform pulse shaping to preserve timing information. To determine the column position for charge pulses, a two-stage summing amplifier configuration is used with weighting amplifiers controlling the relative gain of the second-stage amplifier with respect to respective columns in the array. Each detector element in the array is a silicon photomultiplier (e.g., Geiger-mode avalanched photodiodes biased above breakdown voltage). Position information can be generated by Anger logic on four outputs from the second-stage amplifiers. Energy and timing information can be generated as a sum of the four outputs from the second-stage amplifiers.

公开(公告)号：US11835668B2

公开(公告)日：2023-12-05

申请号：US17345823

申请日：2021-06-11

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Yi Qiang ,  Kent C. Burr ,  Peng Peng ,  Xiaoli Li

IPC: A61B6/03 ,  G01T1/29 ,  A61B6/00

CPC classification number: G01T1/2985 ,  A61B6/037 ,  A61B6/5258

Abstract: A circuit for receiving signals from a photodetector array arranged to detect signals generated by a crystal includes a plurality of summing circuits having weighting circuits, the summing circuits being configured to produce outputs corresponding to a total energy of the signals, a position of the signals in a first dimension of the photodetector array, a position of the signals in a second dimension of the photodetector array, and a radius of a charge distribution of the signals.

公开(公告)号：US12007513B2

公开(公告)日：2024-06-11

申请号：US17581005

申请日：2022-01-21

Applicant: CANON MEDICAL SYSTEMS CORPORATION

Inventor： Peng Peng ,  Yi Qiang ,  Xiaoli Li ,  Kent C. Burr ,  Manabu Teshigawara

IPC: G01T1/20 ,  A61B6/03 ,  A61B6/42 ,  G01T1/164 ,  G01T1/29

CPC classification number: G01T1/1642 ,  A61B6/037 ,  A61B6/4258 ,  G01T1/1644 ,  G01T1/2018 ,  G01T1/2985

Abstract: A method and apparatuses for a radiation detector apparatus, comprising a scintillator array comprising a plurality of scintillator crystals. The plurality of scintillator crystals includes a first scintillator crystal and a second scintillator crystal adjacent to the first scintillator crystal within the scintillator array. A photosensor array comprising a plurality of photosensors including a first photosensor configured to detect photons from the first scintillator crystal. A first separator positioned between the first scintillator crystal and the second scintillator crystal. First separator optically separates the first scintillator crystal and the second scintillator crystal such that the first photosensor detects photons from the first scintillator crystal and not from the second scintillator crystal.