公开(公告)号：US20200347433A1

公开(公告)日：2020-11-05

申请号：US16848651

申请日：2020-04-14

Applicant: CAP DIAGNOSTICS, LLC, DBA PATHNOSTICS

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir ,  Natalie Luke

IPC: C12Q1/08 ,  G01N21/59

Abstract: Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.

公开(公告)号：US20210301315A1

公开(公告)日：2021-09-30

申请号：US17335767

申请日：2021-06-01

Applicant: CAP DIAGNOSTICS, LLC, DBA PATHNOSTICS

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir ,  Natalie Luke

IPC: C12Q1/08 ,  G01N21/59

Abstract: Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.

公开(公告)号：US20210172000A1

公开(公告)日：2021-06-10

申请号：US17178091

申请日：2021-02-17

Applicant: CAP DIAGNOSTICS, LLC, DBA PATHNOSTICS

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir ,  Natalie Luke

IPC: C12Q1/08 ,  G01N21/59

Abstract: Methods for identifying and providing therapeutic solutions for treating polymicrobial infections, such as but not limited to urinary tract infections. The methods herein feature detection and identification of organisms of the polymicrobial infection, phenotypic pooled sensitivity tests for determining the susceptibility or resistance of the polymicrobial infection in the sample to an antibiotic or other therapeutic agent, and identification of resistance genes, e.g., genetic markers that may indicate resistance to a particular treatment. Together, the data can be applied against databases of antibiotic/therapeutic susceptibility or resistance for particular known polymicrobial infections in order to provide one or more therapeutic solutions for the polymicrobial infection.

公开(公告)号：US20190153501A1

公开(公告)日：2019-05-23

申请号：US16216751

申请日：2018-12-11

Applicant: CAP Diagnostics, LLC, dba Pathnostics

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir

IPC: C12Q1/08 ,  G01N21/59

Abstract: Disclosed herein are methods determining susceptibility of bacteria in a sample from a subject suspected of having an infection to a plurality of antibiotics simultaneously, wherein the sample is tested without first isolating the bacteria from the sample.

公开(公告)号：US20240425897A1

公开(公告)日：2024-12-26

申请号：US18824184

申请日：2024-09-04

Applicant: CAP Diagnostics, LLC dba Pathnostics

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir ,  Natalie Luke

IPC: C12Q1/08 ,  G01N21/59

Abstract: Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.

公开(公告)号：US20230392185A1

公开(公告)日：2023-12-07

申请号：US18451748

申请日：2023-08-17

Applicant: CAP DIAGNOSTICS, LLC, DBA PATHNOSTICS

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir ,  Natalie Luke

IPC: C12Q1/08 ,  G01N21/59

CPC classification number: C12Q1/08 ,  G01N21/59 ,  G01N2021/593 ,  G01N21/5907

Abstract: Methods for identifying and providing information about inhibiting growth of polymicrobial infections, including but not limited to providing statistics or information about the likelihood of success in inhibiting growth of a polymicrobial infection with particular compositions or therapeutic solutions. The methods herein feature detection and identification of organisms of the polymicrobial sample (e.g., polymicrobial infection), phenotypic pooled sensitivity tests for determining the susceptibility or resistance of the polymicrobial sample (e.g., polymicrobial infection) in the sample to an antibiotic or other therapeutic agent, and identification of resistance genes, e.g., genetic markers that may indicate resistance to a particular treatment. Together, the data can be applied against databases of antibiotic/therapeutic susceptibility or resistance for particular known polymicrobial samples (e.g., polymicrobial infections) in order to provide information related to the likelihood of success of one or more therapeutic solutions for the polymicrobial sample (e.g., polymicrobial infection).

公开(公告)号：US20230357818A1

公开(公告)日：2023-11-09

申请号：US18351385

申请日：2023-07-12

Applicant: CAP DIAGNOSTICS, LLC, DBA PATHNOSTICS

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir ,  Natalie Luke

IPC: C12Q1/08 ,  G01N21/59

CPC classification number: C12Q1/08 ,  G01N21/59 ,  G01N2021/593 ,  G01N21/5907

Abstract: Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.

公开(公告)号：US20230357817A1

公开(公告)日：2023-11-09

申请号：US18351286

申请日：2023-07-12

Applicant: CAP DIAGNOSTICS, LLC, DBA PATHNOSTICS

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir ,  Natalie Luke

IPC: C12Q1/08 ,  G01N21/59

CPC classification number: C12Q1/08 ,  G01N21/59 ,  G01N2021/593 ,  G01N21/5907

Abstract: Methods for detecting and treating polymicrobial infections, wherein a mixed population of microbes (e.g., bacteria) are present in a patient sample and the microbes are not first isolated from the sample. For example, the present invention describes specific polymicrobial infections and methods of treating said infections, wherein a particular antibiotic or a group of antibiotics are selected based on the composition of the polymicrobial infections.

公开(公告)号：US20180305730A1

公开(公告)日：2018-10-25

申请号：US15957780

申请日：2018-04-19

Applicant: CAP Diagnostics, LLC, dba Pathnostics

Inventor： David A. Baunoch ,  Miguel F.R. Penaranda ,  Michael L. Opel ,  Maher Badir

IPC: C12Q1/08 ,  G01N21/59

CPC classification number: C12Q1/08 ,  G01N21/59 ,  G01N21/5907 ,  G01N2021/593

Abstract: Disclosed herein are methods determining susceptibility of bacteria in a sample from a subject suspected of having an infection to a plurality of antibiotics simultaneously, wherein the sample is tested without first isolating the bacteria from the sample.