公开(公告)号：US20170268008A1

公开(公告)日：2017-09-21

申请号：US15529399

申请日：2015-11-24

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Ahmed Khalil ,  Sanford Markowitz

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1137 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/113 ,  C12N2310/10 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2320/11 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Y201/01037 ,  G01N33/50 ,  G01N33/574

Abstract: A method for treating cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of DNMT1-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in the cancer cells of the subject. Embodiments described herein relate to RNAs (e.g., IncRNAs) associated with DNA methyltransferase 1 (DNMTI-associated RNA) in human cancer cells, methods and compositions of modulating the levels of DNMTI-associated RNA and/or the interaction of DNMT1-associated RNA and DNMT1 in cancer cells of the subject to treat cancer cells or a subject in need thereof, and/or methods of measuring the expression profile of DNMT1 associated RNA to determine whether the subject has cancer or an increased risk of cancer and/or the efficacy of a therapeutic regimen agent.