公开(公告)号：US20220280663A1

公开(公告)日：2022-09-08

申请号：US17745016

申请日：2022-05-16

申请人： CELLIS AG

发明人： Magdalena KROL ,  Irene BENNI ,  Paola BAIOCCO ,  Tomasz RYGIEL ,  Alberto BOFFI ,  Aleksandra SZULC ,  Zofia PILCH ,  Katarzyna TONECKA ,  Katarzyna ULEWICZ ,  Bartlomiej TACIAK ,  Lukasz KIRAGA

IPC分类号： A61K51/12 ,  A61K47/68 ,  A61K47/64 ,  A61K47/69 ,  A61K35/15 ,  A61K35/17 ,  A61K45/06 ,  A61K49/00 ,  A61K49/18 ,  A61K51/04 ,  C12N5/0783 ,  C12N5/0787 ,  C12N5/0786

摘要： The present invention relates to an isolated cellular targeted delivery system comprising a CD45+ leukocyte cell comprising within said cell a complex of one or more iron binding proteins and an active pharmaceutically active substance and/or label as well as methods for producing such isolated cellular targeted delivery system and uses of such system for prophylaxis, therapy, diagnosis or theragnosis, in particular for prophylactic or therapeutic vaccination, therapy of cancer, particularly metastatic cancer or inflammatory diseases.

公开(公告)号：US20240060045A1

公开(公告)日：2024-02-22

申请号：US17931576

申请日：2022-09-13

申请人： CELLIS AG

发明人： Magdalena KROL ,  Irene BENNI ,  Paola BAIOCCO ,  Tomasz RYGIEL ,  Alberto BOFFI

IPC分类号： C12N5/0786 ,  A61K35/15 ,  A61K47/64 ,  A61K45/00 ,  A61K47/69 ,  A61P35/00

CPC分类号： C12N5/0645 ,  A61K35/15 ,  A61K47/644 ,  A61K45/00 ,  A61K47/69 ,  A61P35/00

摘要： The present invention relates to an isolated cellular targeted delivery system comprising a CD45+ leukocyte cell comprising within said cell a complex of one or more iron binding proteins and an active ingredient as well as methods for producing such isolated cellular targeted delivery system and uses of such system for therapy, in particular for therapy of cancer.