公开(公告)号：US20030049697A1

公开(公告)日：2003-03-13

申请号：US10243035

申请日：2002-09-13

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, C.N.R.S.

Inventor： Michel Lazdunski ,  Florian Lesage ,  Francois Maingret

IPC: G01N033/567

CPC classification number: C07K14/705 ,  A61K38/00

Abstract: A mechanosensitive human potassium channel, referred to as nullhTRAAKnull for human TWICK-Related AA-Activated Knull channel, which is activated by polyunsaturated fatty acids as well as by the neuroprotective agent riluzole. The properties of the channels of the TRAAK family as well as their tissue distribution give these channels a primordial role in the transport of potassium in a large number of cell types.

Abstract translation: 机械敏感的人类钾通道，被称为“hTRAAK”用于人类TWICK相关AA激活的K +通道，其由多不饱和脂肪酸以及由神经保护剂利鲁唑激活。 TRAAK家族的通道的特性及其组织分布使得这些通道在大量细胞类型中的钾的输送中起原始作用。