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    CISPLATIN COMPLEX AND PREPARATION METHOD THEREOF
    1.
    发明申请
    CISPLATIN COMPLEX AND PREPARATION METHOD THEREOF 有权
    CISPLATIN复合物及其制备方法

    公开(公告)号：US20150231273A1

    公开(公告)日：2015-08-20

    申请号：US14434731

    申请日：2013-03-26

    申请人： CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCE

    发明人： Zhaohui Tang ,  Haiyang Yu ,  Wantong Song ,  Mingqiang Li ,  Xiuli Zuang ,  Xuesi Chen

    IPC分类号： A61K47/48 ,  C08G81/00 ,  A61K33/24

    CPC分类号： C08G81/00 ,  A61K33/24 ,  A61K47/60 ,  A61K47/64 ,  A61K47/645 ,  C08G69/10 ,  C08G69/40 ,  C08L77/04

    摘要： A CDDP complex is formed by complexation of CDDP and a polymer having a structure of Formula (I). The CDDP complex has good biocompatibility and is degradable. A side chain of the polymer is grafted with polyethylene glycol, which gives the CDDP complex good dissolvability. When dissolved in an aqueous medium, the CDDP is protected by a hydrophilic polyethylene glycol chain segment and a hydrophobic amino acid chain segment, which can effectively avoid a sudden release of the CDDP due to the influence of the blood circulation system after intravenous injection, thus improving the stability of the CDDP complex. A carboxyl group contained in the CDDP complex has pH value sensitivity and tends to be deprotonated in a low pH environment, which is advantageous for promoting the release of a drug, and improving the efficiency of the drug.

    摘要翻译： 通过CDDP与具有式（I）结构的聚合物的络合形成CDDP复合物。 CDDP复合物具有良好的生物相容性，是可降解的。 聚合物的侧链用聚乙二醇接枝，这使得CDDP复合物具有良好的溶解性。 当溶解在水性介质中时，CDDP被亲水性聚乙二醇链段和疏水性氨基酸链段保护，这可以有效地避免由于静脉注射后血液循环系统的影响，CDDP突然释放，因此 提高CDDP复合物的稳定性。 CDDP复合物中所含的羧基具有pH值敏感性，并且在低pH环境中倾向于去质子化，这有利于促进药物的释放并提高药物的效率。