公开(公告)号：US12024490B2

公开(公告)日：2024-07-02

申请号：US17334166

申请日：2021-05-28

申请人： CHELATION PARTNERS INCORPORATED

发明人： Bruce E. Holbein ,  M. Trisha C. Ang ,  Dnyaneshwar Vithoba Palaskar ,  Ganugapati Satyanarayana ,  Gireesh Mahandru ,  S. Vijaya Bhaskara Reddy ,  Sazid Ali

IPC分类号： C07D213/69 ,  A61K31/787 ,  A61P39/04 ,  C08F220/54 ,  C08F220/60 ,  C08F226/10

CPC分类号： C07D213/69 ,  A61K31/787 ,  A61P39/04 ,  C08F220/54 ,  C08F220/60 ,  C08F226/10 ,  C08F2438/03 ,  C08F220/603 ,  C08F220/54 ,  C08F226/10 ,  C08F220/603 ,  C08F220/54 ,  C08F220/603

摘要： Disclosed are chelating co-polymer compositions that are soluble in aqueous media and chelate essential metals, methods of preparation and uses thereof. The chelating compositions are comprised of two or more different monomers, at least one of which possesses metal binding or metal chelating activity. The chelating compositions are synthesized by reversible addition-fragmentation transfer (RAFT) polymerization with the aid of a suitable RAFT-mediating agent. Also described are chelating compositions that comprise hydroxypyridinone chelating groups. The ability of the chelating compositions to bind metals affects the activity of a living cells and organisms, which require the metals for cellular functions.

公开(公告)号：US11059785B2

公开(公告)日：2021-07-13

申请号：US16327694

申请日：2017-08-25

申请人： CHELATION PARTNERS INCORPORATED

发明人： Bruce E. Holbein ,  M. Trisha C. Ang ,  Dnyaneshwar Vithoba Palaskar ,  Ganugapati Satyanarayana ,  Gireesh Mahandru ,  S. Vijaya Bhaskara Reddy ,  Sazid Ali

IPC分类号： C07D213/69 ,  A61K31/787 ,  C08F220/60 ,  A61P39/04 ,  C08F220/54 ,  C08F226/10

摘要： Disclosed are chelating co-polymer compositions that are soluble in aqueous media and chelate essential metals, methods of preparation and uses thereof. The chelating compositions are comprised of two or more different monomers, at least one of which possesses metal binding or metal chelating activity. The chelating compositions are synthesized by reversible addition-fragmentation transfer (RAFT) polymerization with the aid of a suitable RAFT-mediating agent. Also described are chelating compositions that comprise hydroxypyridinone chelating groups. The ability of the chelating compositions to bind metals affects the activity of a living cells and organisms, which require the metals for cellular functions.

公开(公告)号：US20220002250A1

公开(公告)日：2022-01-06

申请号：US17334166

申请日：2021-05-28

申请人： CHELATION PARTNERS INCORPORATED

发明人： Bruce E. Holbein ,  M. Trisha C. Ang ,  Dnyaneshwar Vithoba Palaskar ,  Ganugapati Satyanarayana ,  Gireesh Mahandru ,  S. Vijaya Bhaskara Reddy ,  Sazid Ali

IPC分类号： C07D213/69 ,  A61K31/787 ,  C08F220/60 ,  A61P39/04 ,  C08F220/54 ,  C08F226/10

摘要： Disclosed are chelating co-polymer compositions that are soluble in aqueous media and chelate essential metals, methods of preparation and uses thereof. The chelating compositions are comprised of two or more different monomers, at least one of which possesses metal binding or metal chelating activity. The chelating compositions are synthesized by reversible addition-fragmentation transfer (RAFT) polymerization with the aid of a suitable RAFT-mediating agent. Also described are chelating compositions that comprise hydroxypyridinone chelating groups. The ability of the chelating compositions to bind metals affects the activity of a living cells and organisms, which require the metals for cellular functions.

公开(公告)号：US20190169126A1

公开(公告)日：2019-06-06

申请号：US16327694

申请日：2017-08-25

申请人： CHELATION PARTNERS INCORPORATED

发明人： Bruce E. Holbein ,  M. Trisha C. Ang ,  Dnyaneshwar Vithoba Palaskar ,  Ganugapati Satyanarayana ,  Gireesh Mahandru ,  S. Vijaya Bhaskara Reddy ,  Sazid Ali

IPC分类号： C07D213/69 ,  A61K31/787 ,  A61P39/04 ,  C08F220/60

摘要： Disclosed are chelating co-polymer compositions that are soluble in aqueous media and chelate essential metals, methods of preparation and uses thereof. The chelating compositions are comprised of two or more different monomers, at least one of which possesses metal binding or metal chelating activity. The chelating compositions are synthesized by reversible addition-fragmentation transfer (RAFT) polymerization with the aid of a suitable RAFT-mediating agent. Also described are chelating compositions that comprise hydroxypyridinone chelating groups. The ability of the chelating compositions to bind metals affects the activity of a living cells and organisms, which require the metals for cellular functions.