公开(公告)号：US11123310B2

公开(公告)日：2021-09-21

申请号：US15441424

申请日：2017-02-24

申请人： CHEMAPOTHECA, LLC ,  PHARMAPOTHECA, LLC

发明人： Karl Popp ,  Harold Meckler

IPC分类号： A61K31/137 ,  A61K9/20 ,  A61K9/00 ,  A61K9/48 ,  A61K47/64 ,  A61K9/50 ,  A61K47/54 ,  A61K9/28

摘要： The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

公开(公告)号：US11717498B2

公开(公告)日：2023-08-08

申请号：US17066488

申请日：2020-10-09

申请人： CHEMAPOTHECA, LLC

发明人： Karl Popp ,  Harold Meckler

IPC分类号： A61K31/137 ,  A61K47/64 ,  A61K9/50 ,  A61K47/54 ,  A61K9/20 ,  A61K9/28

CPC分类号： A61K31/137 ,  A61K9/2031 ,  A61K9/2866 ,  A61K9/5026 ,  A61K9/5047 ,  A61K47/542 ,  A61K47/64

摘要： The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.

公开(公告)号：US20180243241A1

公开(公告)日：2018-08-30

申请号：US15441424

申请日：2017-02-24

申请人： CHEMAPOTHECA, LLC

发明人： Karl Popp ,  Harold Meckler

IPC分类号： A61K31/137 ,  A61K9/20 ,  A61K9/00 ,  A61K9/48

CPC分类号： A61K31/137 ,  A61K9/2031 ,  A61K9/2866 ,  A61K9/5026 ,  A61K9/5047 ,  A61K47/542 ,  A61K47/64

摘要： The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.