公开(公告)号：US20220185774A1

公开(公告)日：2022-06-16

申请号：US17425701

申请日：2019-09-27

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

发明人： Yinsheng ZHANG ,  Wangwei AO ,  Yuan LI ,  Hui WANG ,  Hangzhou SHEN ,  Jie NI ,  Huan ZHANG ,  Jie WU ,  Li ZHANG ,  Kai CAO ,  Peng LU ,  Xushi LIU ,  Jie WANG ,  Tianxiao ZHAO ,  Xingfeng GE ,  Dandan LU ,  Shuo CHEN ,  Xueqin MA ,  Wei SHI ,  Xiaojin WANG ,  Hongjiang XU

IPC分类号： C07D207/34 ,  A61P31/20

摘要： Provided is a compound of formula I or II, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and the medical uses thereof in treating diseases benefiting from the capsid protein assembly inhibitor, particularly diseases caused by hepatitis B virus infection.

公开(公告)号：US20210017154A1

公开(公告)日：2021-01-21

申请号：US17043593

申请日：2019-03-29

申请人： CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

发明人： Yinsheng ZHANG ,  Wangwei AO ,  Yuan LI ,  Hui WANG ,  Hangzhou SHEN ,  Jie NI ,  Huan ZHANG ,  Jie WU ,  Li ZHANG ,  Kai CAO ,  Peng LU ,  Xushi LIU ,  Jie WANG ,  Tianxiao ZHAO ,  Xingfeng GE ,  Dandan LU ,  Shuo CHEN ,  Xueqin MA ,  Wei SHI ,  Xiaojin WANG ,  Hongjiang XU

IPC分类号： C07D401/12 ,  C07D207/34 ,  C07D405/12 ,  C07D409/12

摘要： A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.