公开(公告)号：US20230183208A1

公开(公告)日：2023-06-15

申请号：US18106103

申请日：2023-02-06

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

Inventor： Yinsheng Zhang ,  Wangwei Ao ,  Yuan Li ,  Hui Wang ,  Hangzhou Shen ,  Jie Ni ,  Huan Zhang ,  Jie Wu ,  Li Zhang ,  Kai Cao ,  Peng Lu ,  Xushi Liu ,  Jie Wang ,  Tianxiao Zhao ,  Xingfeng Ge ,  Dandan Lu ,  Shuo Chen ,  Xueqin Ma ,  Wei Shi ,  Xiaojin Wang ,  Hongjiang Xu

IPC: C07D401/12 ,  C07D207/34 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D401/12 ,  C07D207/34 ,  C07D405/12 ,  C07D409/12

Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.

公开(公告)号：US11597716B2

公开(公告)日：2023-03-07

申请号：US17043593

申请日：2019-03-29

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

Inventor： Yinsheng Zhang ,  Wangwei Ao ,  Yuan Li ,  Hui Wang ,  Hangzhou Shen ,  Jie Ni ,  Huan Zhang ,  Jie Wu ,  Li Zhang ,  Kai Cao ,  Peng Lu ,  Xushi Liu ,  Jie Wang ,  Tianxiao Zhao ,  Xingfeng Ge ,  Dandan Lu ,  Shuo Chen ,  Xueqin Ma ,  Wei Shi ,  Xiaojin Wang ,  Hongjiang Xu

IPC: C07D401/12 ,  C07D207/34 ,  C07D405/12 ,  C07D409/12

Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.

公开(公告)号：US12116356B2

公开(公告)日：2024-10-15

申请号：US18106103

申请日：2023-02-06

Applicant: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

Inventor： Yinsheng Zhang ,  Wangwei Ao ,  Yuan Li ,  Hui Wang ,  Hangzhou Shen ,  Jie Ni ,  Huan Zhang ,  Jie Wu ,  Li Zhang ,  Kai Cao ,  Peng Lu ,  Xushi Liu ,  Jie Wang ,  Tianxiao Zhao ,  Xingfeng Ge ,  Dandan Lu ,  Shuo Chen ,  Xueqin Ma ,  Wei Shi ,  Xiaojin Wang ,  Hongjiang Xu

IPC: C07D401/12 ,  C07D207/34 ,  C07D405/12 ,  C07D409/12

CPC classification number: C07D401/12 ,  C07D207/34 ,  C07D405/12 ,  C07D409/12

Abstract: A N-heterocyclic five-membered ring-containing capsid protein assembly inhibitor, and a pharmaceutical composition and use thereof, specifically relating to a compound as represented by formula I, a stereoisomer, a tautomer, a geometrical isomer, a solvate, an active metabolite, a hydrate, a prodrug or a pharmaceutically acceptable salt thereof, a pharmaceutical composition thereof, and a medical use thereof. The medical use comprises the use in treating diseases benefiting from the capsid protein assembly inhibitor, and in particular, diseases caused by hepatitis B virus infection.