公开(公告)号：US11542261B2

公开(公告)日：2023-01-03

申请号：US16804518

申请日：2020-02-28

申请人： CHILDREN'S HOSPITAL MEDICAL CENTER ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES

发明人： Daniel T. Starczynowski ,  Craig J. Thomas ,  Garrett Rhyasen ,  Katelyn Melgar ,  Morgan MacKenzie Walker ,  Jian-kang Jiang

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61K31/496

摘要： Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as head and neck squamous cell carcinoma (HNSCC), cancer, blood disorders, etc.). Additional embodiments provide synergistic combinations of a BCL2 inhibitor with an IRAK inhibiting compound, and methods of using same.

公开(公告)号：US20220235042A1

公开(公告)日：2022-07-28

申请号：US17587070

申请日：2022-01-28

申请人： CHILDREN'S HOSPITAL MEDICAL CENTER ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPT. OF HEALTH AND HUMAN SERVICES

发明人： Daniel T. STARCZYNOWSKI ,  Craig J. Thomas ,  Garrett Rhyasen ,  Katelyn Melgar ,  Morgan MacKenzie Walker ,  Jian-Kang Jiang

IPC分类号： C07D471/04 ,  A61K31/496

摘要： Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as head and neck squamous cell carcinoma (HNSCC), cancer, blood disorders, etc.). Additional embodiments provide synergistic combinations of a BCL2 inhibitor with an IRAK inhibiting compound, and methods of using same.

公开(公告)号：US11254667B2

公开(公告)日：2022-02-22

申请号：US16326571

申请日：2017-08-16

申请人： CHILDREN'S HOSPITAL MEDICAL CENTER ,  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Daniel T. Starczynowski ,  Craig J. Thomas ,  Garrett Rhyasen ,  Katelyn Melgar ,  Morgan MacKenzie Walker ,  Jian-kang Jiang

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61P35/02

摘要： Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)). Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as cancer or blood disorders). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.