专利检索 ap:("CHINA PHARMACEUTICAL UNIVERSITY") AND inv:"Qi Dong YOU" 第 1 页

1.

发明申请
ANILINE-BASED WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR, AND PREPARATION METHOD AND USE THEREOF 有权

公开(公告)号：US20220152027A1

公开(公告)日：2022-05-19

申请号：US17434353

申请日：2019-03-22

申请人： CHINA PHARMACEUTICAL UNIVERSITY

发明人： Qi Dong YOU , Xiaoke GUO , Weilin CHEN , Dongdong LI , Jing GU , Jun XU , Xin CHEN , Zhengyu JIANG , Xiaoli XU

IPC分类号： A61K31/517 , A61P35/00 , A61K31/506 , A61K31/5355

摘要： The present disclosure discloses a WDR5 protein-protein interaction inhibitor, including a compound having a structure represented by general formula (I). Experiments show that the inhibitor acts on a WDR5 protein and an interacting protein thereof including, but not limited to, MLL, selectively inhibits the proliferation of leukemia cells, and inhibits the methylation of H3K4 and the expression of downstream Hox/Meis-1 gene at the cellular level. The present disclosure also discloses a method for preparing the inhibitor and use thereof in the preparation of a drug for treating acute leukemia and other related diseases.