公开(公告)号：US10442759B2

公开(公告)日：2019-10-15

申请号：US15755356

申请日：2016-11-25

申请人： CHINA PHARMACEUTICAL UNIVERSITY

发明人： Qidong You ,  Zhengyu Jiang ,  Mengchen Lu ,  Zhiyun Chen ,  Haopeng Sun ,  Xiaojin Zhang ,  Xiaoke Guo ,  Xiaoli Xu

IPC分类号： C07C311/21 ,  C07C303/38 ,  C07C311/29 ,  C07D257/04 ,  A61P9/10 ,  A61P25/28 ,  A61P3/10 ,  A61P11/00 ,  A61P25/16 ,  C07C303/08 ,  C07C311/46

摘要： Compounds of formula (I) having 1-sulfonamido-4-aryloxy as a basic backbone. A preliminary activity test showed that the compounds provide excellent interference of a binding of Nrf2 by Keap1, thereby activating Nrf2. The compounds have a potential anti-inflammatory activity and can be used to treat a plurality of inflammation-associated diseases, including chronic obstructive pulmonary disease (COPD), Alzheimer's disease, Parkinson's disease, atherosclerosis, chronic kidney disease (CKD), diabetes, gastroenteritis, rheumatoid arthritis, and the like.