公开(公告)号：US20090118487A1

公开(公告)日：2009-05-07

申请号：US12249843

申请日：2008-10-10

申请人： CHRISTOPHER TODD BAUER ,  MAUREEN JERI BOURNER ,  MELANIE BOYLE ,  GERALD FRIES CASPERSON ,  DAVID WILLIAM GRIGGS ,  RICHARD DAVID HEAD ,  WILLIAM DEAN JOY ,  RICHARD ALLEN MAZZARELLA ,  RALPH RAYMOND MINTER ,  MARK ALLEN MOFFAT ,  BARRETT RICHARD THIELE ,  TODD LEE VANARSDALE

发明人： CHRISTOPHER TODD BAUER ,  MAUREEN JERI BOURNER ,  MELANIE BOYLE ,  GERALD FRIES CASPERSON ,  DAVID WILLIAM GRIGGS ,  RICHARD DAVID HEAD ,  WILLIAM DEAN JOY ,  RICHARD ALLEN MAZZARELLA ,  RALPH RAYMOND MINTER ,  MARK ALLEN MOFFAT ,  BARRETT RICHARD THIELE ,  TODD LEE VANARSDALE

IPC分类号： C07H21/04

CPC分类号： C07K16/28 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  Y02P20/582

摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to P-cadherin, and that function to inhibit P-cadherin. The invention also relates to heavy and light chain immunoglobulins derived from human P-cadherin antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human P-cadherin antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

摘要翻译： 本发明涉及结合P-钙粘蛋白的人抗体及其抗原结合部分的抗体，其功能是抑制P-钙粘蛋白。 本发明还涉及衍生自人P-钙粘蛋白抗体的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人P-钙粘蛋白抗体的方法，包含这些抗体的组合物和使用抗体和组合物的方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。