公开(公告)号：US11370747B2

公开(公告)日：2022-06-28

申请号：US16607443

申请日：2018-04-25

申请人： CHUBU UNIVERSITY EDUCATIONAL FOUNDATION

发明人： Hisashi Yamamoto ,  Wataru Muramatsu ,  Tomohiro Hattori ,  Yasushi Shimoda ,  Hiroaki Tsuji

IPC分类号： C07C231/02 ,  C07C231/12 ,  C07C269/06 ,  B01J31/02 ,  B01J31/36 ,  C07C237/12 ,  C07C271/20 ,  C07C271/22

摘要： Provided is a novel method for producing amide compounds at high stereochemical selectivities. The method according to the present invention for producing amide compounds is provided with an amidation step for reacting, in the presence of a catalyst comprising a metal compound, an amino compound with an aminoester compound represented by general formula (1) to amidate the ester group in the aminoester compound.

公开(公告)号：US11512108B2

公开(公告)日：2022-11-29

申请号：US17047464

申请日：2019-04-25

申请人： CHUBU UNIVERSITY EDUCATIONAL FOUNDATION

发明人： Hisashi Yamamoto ,  Wataru Muramatsu ,  Tomohiro Hattori

IPC分类号： C07K1/08 ,  C07K1/00 ,  C07C231/02 ,  C07K1/02

摘要： Provided is a novel method whereby an amide compound can be produced by highly stereoselectively and efficiently performing amidation between a plurality of amino acids and/or peptides. A compound of general formula (3) is synthesized by forming an amide bond between the carboxyl group on the right side of general formula (1) in a compound represented thereby and the amino group on the left side of general formula (2) in a compound represented thereby, in the presence of a Lewis acid catalyst and a silylating agent [in formulae (1), (2) and (3), each symbol has the same meaning as defined in claims].