专利检索 ap:("CHUGAI SEIYAKU KABUSHIKI KAISHA") AND inv:"Hiroshi Hino" 第 1 页

1.

发明授权
Gene-modified mouse expressing human GPC3 polypeptide 有权

公开(公告)号：US11793180B2

公开(公告)日：2023-10-24

申请号：US16327218

申请日：2017-08-21

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人： Koichi Jishage , Hiroshi Hino , Takahiro Ishiguro , Yasuko Kinoshita

IPC分类号： A01K67/027 , C12N15/85 , G01N33/50 , C07K16/28 , C07K16/30 , C12N5/10 , C07K14/705 , A61K39/00

CPC分类号： A01K67/0278 , C07K14/705 , C07K16/2809 , C07K16/303 , C12N5/10 , C12N15/85 , G01N33/5041 , G01N33/5088 , A01K2217/052 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A61K2039/505 , C07K2317/31 , C12N2015/8518

摘要： Genetically modified non-human animals which are deficient in expression of an endogenous GPC3 polypeptide and express a human GPC3 polypeptide at a physiologically adequate level; methods for producing the non-human animals; and methods for evaluating test substances using the non-human animals. Furthermore, methods for evaluating test substances regarding their safety, therapeutic effects on diseases, pharmacokinetics, in vivo distribution, and such, using the non-human animals as models.