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公开(公告)号：US20140039165A1
公开(公告)日：2014-02-06
申请号：US14047316
申请日：2013-10-07
发明人： Taichi Kuramochi , Keiko Kasutani , Souhei Ohyama , Hiroyuki Tsunoda , Tomoyuki Igawa , Tatsuhiko Tachibana , Hirotake Shiraiwa , Keiko Esaki
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/7155
摘要： The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases.
摘要翻译： 本发明人成功获得了抗NR10抗体的抗NR10抗体。 本发明提供的抗NR10抗体可用作例如用于治疗或预防炎性疾病的药物。
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公开(公告)号：US20150315280A1
公开(公告)日：2015-11-05
申请号：US14680154
申请日：2015-04-07
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/54 , C07K14/715 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present inventors obtained, from a phage library of human antibodies, an anti-mouse NR 10 neutralizing antibody-expressing BM095 clone that shows a strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When this anti-mouse NR 10 neutralizing antibody was administered to NC/Nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that the anti-NR 10 neutralizing antibody is indeed effective as a therapeutic agent for inflammatory diseases. In addition, the present inventors successfully obtained an anti-human NR 10 neutralizing antibody, providing extremely useful therapeutic agents with practical clinical applications.
摘要翻译： 本发明人从人抗体的噬菌体文库获得了在IL-31依赖性Ba / F3细胞增殖分析系统中显示出强的增殖抑制活性的抗小鼠NR10中和抗体表达BM095克隆。 当向NC / Nga小鼠施用这种抗小鼠NR 10中和抗体时，是由于重复使用苦基氯，类风湿性关节炎的小鼠模型和由此引起的慢性皮炎小鼠模型的特应性皮炎模型 观察到骨关节炎的小鼠模型，观察到症状抑制的显着作用。 这表明抗NR10中和抗体确实作为炎性疾病的治疗剂有效。 此外，本发明人成功地获得了抗人NR10中和抗体，其具有实用的临床应用的非常有用的治疗剂。
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公开(公告)号：US09745378B2
公开(公告)日：2017-08-29
申请号：US14680154
申请日：2015-04-07
IPC分类号： C07K16/28 , A61K39/395 , C07K14/715 , C07K14/54 , A61K39/00
CPC分类号： C07K16/2866 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/54 , C07K14/715 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2319/00
摘要： The present inventors obtained, from a phage library of human antibodies, an anti-mouse NR 10 neutralizing antibody-expressing BM095 clone that shows a strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When this anti-mouse NR 10 neutralizing antibody was administered to NC/Nga mice, a model of atopic dermatitis which is a mouse model of chronic dermatitis that arises as a result of repeated applications of picryl chloride, a mouse model of rheumatoid arthritis, and a mouse model of osteoarthritis, a significant effect of symptom suppression was observed. This revealed that the anti-NR 10 neutralizing antibody is indeed effective as a therapeutic agent for inflammatory diseases. In addition, the present inventors successfully obtained an anti-human NR 10 neutralizing antibody, providing extremely useful therapeutic agents with practical clinical applications.
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公开(公告)号：US20150175704A1
公开(公告)日：2015-06-25
申请号：US14340883
申请日：2014-07-25
发明人： Taichi Kuramochi , Keiko Kasutani , Souhei Ohyama , Hiroyuki Tsunoda , Tomoyuki Igawa , Tatsuhiko Tachibana , Hirotake Shiraiwa , Keiko Esaki
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/7155
摘要： The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases.
摘要翻译： 本发明人成功获得了抗NR10抗体的抗NR10抗体。 本发明提供的抗NR10抗体可用作例如用于治疗或预防炎性疾病的药物。
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公开(公告)号：US20240294653A1
公开(公告)日：2024-09-05
申请号：US18661829
申请日：2024-05-13
发明人： Taichi Kuramochi , Keiko Kasutani , Souhei Ohyama , Hiroyuki Tsunoda , Tomoyuki Igawa , Tatsuhiko Tachibana , Hirotake Shiraiwa , Keiko Esaki
CPC分类号： C07K16/2866 , G01N33/6869 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N2333/7155
摘要： The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases.
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公开(公告)号：US20230183363A1
公开(公告)日：2023-06-15
申请号：US17975865
申请日：2022-10-28
发明人： Taichi Kuramochi , Keiko Kasutani , Souhei Ohyama , Hiroyuki Tsunoda , Tomoyuki Igawa , Tatsuhiko Tachibana , Hirotake Shiraiwa , Keiko Esaki
CPC分类号： C07K16/2866 , G01N33/6869 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92 , C07K2317/76 , A61K2039/505
摘要： The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases.
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公开(公告)号：US20200002429A1
公开(公告)日：2020-01-02
申请号：US16560143
申请日：2019-09-04
发明人： Taichi Kuramochi , Keiko Kasutani , Souhei Ohyama , Hiroyuki Tsunoda , Tomoyuki Igawa , Tatsuhiko Tachibana , Hirotake Shiraiwa , Keiko Esaki
摘要： The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases.
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公开(公告)号：US09399680B2
公开(公告)日：2016-07-26
申请号：US14047316
申请日：2013-10-07
发明人： Taichi Kuramochi , Keiko Kasutani , Souhei Ohyama , Hiroyuki Tsunoda , Tomoyuki Igawa , Tatsuhiko Tachibana , Hirotake Shiraiwa , Keiko Esaki
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/7155
摘要： The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases.
摘要翻译： 本发明人成功获得了抗NR10抗体的抗NR10抗体。 本发明提供的抗NR10抗体可用作例如用于治疗或预防炎性疾病的药物。
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